Inflammation-based assessment for the risk stratification of mortality in patients with heart failure.
Inflammation-based assessment for the risk stratification of mortality in patients with heart failure.
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DOI：
10.1038/s41598-021-94525-6
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发表时间：
2021-07-22
影响因子：
4.6
通讯作者：
Kuwahara K
中科院分区：
文献类型：
--
作者：
Itagaki T;Motoki H;Otagiri K;Machida K;Takeuchi T;Kanai M;Kimura K;Higuchi S;Minamisawa M;Kitabayashi H;Kuwahara K
格拉斯哥预后评分 (GPS) 已成为评估炎症和营养不良以及预测多种癌症预后的有用资源。然而，其对心力衰竭（HF）患者的预后意义尚未明确。为了调查 GPS 与心力衰竭患者死亡率之间的关联，我们评估了 870 名 20 岁及以上且因急性失代偿性心力衰竭入院的患者。如之前报道的那样，GPS 的范围为 0 到 2 点。在 18 个月的随访中（随访率为 83.9%），143 名患者死亡。 GPS 增加与纽约心脏协会功能分级和 B 型利钠肽 (BNP) 水平评估的心力衰竭严重程度升高相关。 Kaplan-Meier 分析显示死亡率与 GPS 增加存在显着关联。在多变量分析中，与 GPS 0 组相比，在调整年龄、性别、血压、心力衰竭病史、心力衰竭严重程度、血红蛋白、肾功能、钠、BNP、左心室射血分数和抗心力衰竭药物后，GPS 2 组与高死亡率相关（风险比 2.92，95% 置信区间 1.77–4.81，p< 0.001）。总之，高 GPS 与心力衰竭患者预后较差显着相关。 GPS 基于炎症的评估可以简单地评估心力衰竭的严重程度和预后。
The Glasgow Prognostic Score (GPS) has been established as a useful resource to evaluate inflammation and malnutrition and predict prognosis in several cancers. However, its prognostic significance in patients with heart failure (HF) is not well established. To investigate the association between the GPS and mortality in patients with HF, we assessed 870 patients who were 20 years old and more and had been admitted for acute decompensated HF. The GPS ranged from 0 to 2 points as previously reported. Over the 18-month follow-up (follow-up rate, 83.9%), 143 patients died. Increasing GPS was associated with higher HF severity assessed by New York Heart Association functional class and B-type natriuretic peptide (BNP) levels. Kaplan–Meier analysis showed significant associations for mortality and increased GPS. In multivariate analysis, compared to the GPS 0 group, the GPS 2 group was associated with high mortality (hazard ratio 2.92, 95% confidence interval 1.77–4.81, p < 0.001) after adjustment for age, sex, blood pressure, HF history, HF severity, hemoglobin, renal function, sodium, BNP, left ventricular ejection fraction, and anti-HF medications. In conclusion, high GPS was significantly associated with worse prognosis in patients with HF. Inflammation-based assessment by the GPS may enable simple evaluation of HF severity and prognosis.
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影响因子：
1.6
作者：
Li MX;Bi XY;Li ZY;Huang Z;Han Y;Zhou JG;Zhao JJ;Zhang YF;Zhao H;Cai JQ
通讯作者：
Cai JQ
对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
DOI：
10.1161/circheartfailure.110.957480
发表时间：
2011-01
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Lee DS;Gona P;Albano I;Larson MG;Benjamin EJ;Levy D;Kannel WB;Vasan RS
通讯作者：
Vasan RS
影响因子：
24
作者：
Goodlin, Sarah J.
通讯作者：
Goodlin, Sarah J.
影响因子：
1.9
作者：
Milo-Cotter, Olga;Cotter-Davison, Beth;Cotter-Davison, Gad
通讯作者：
Cotter-Davison, Gad