Relationship of circulating immune cells with lifestyle factors and cancer recurrence in early-stage breast cancer.
Relationship of circulating immune cells with lifestyle factors and cancer recurrence in early-stage breast cancer.
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DOI：
10.1007/s10549-020-06016-3
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发表时间：
2021-04
影响因子：
3.8
通讯作者：
Santa-Maria, Cesar A.
中科院分区：
文献类型：
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作者：
Xie, Eric;Lapinski, Maya M.;Talamantes, Sarah;Nonyane, Bareng A. S.;Magalhaes, Maria Cristina Figueroa;Visvanathan, Kala;Wolff, Antonio C.;Santa-Maria, Cesar A.
探讨早期乳腺癌患者循环免疫细胞与复发及代谢/生活方式因素的关系。早期乳腺癌患者是从电子记录和机构登记中确定的。淋巴细胞和单核细胞计数在任何化疗前诊断时从血液样品中获得。在整个队列和肥胖患者、饮酒和吸烟患者中评估淋巴细胞和单核细胞与复发的相关性。采用竞争风险回归分析复发时间。共确定了950例随访≥5年的患者; 433例具有完整的数据，符合分析条件。293例（68%）为激素受体阳性乳腺癌，82例（19%）为HER 2阳性，53例（13%）为三阴性。与最低五分位数相比，淋巴细胞最高五分位数的患者复发风险较低（亚危害比（SHR）=0.17，95% CI [0.03-0.93]，p=0.041），而单核细胞最高五分位数的患者复发风险较低（SHR= 0.19，95% CI [0.04，0.92]，p=0.039）。在报告饮酒的患者中，较高的单核细胞与较低的复发率更密切相关（HR= 0.10，95% CI [0.01，0.91]，p=0.04）。在肥胖患者中，较高的淋巴细胞与较低的复发风险相关（p=0.046）;在非肥胖患者中，较高的单核细胞与较低的复发风险相关（p=0.02）。报告吸烟的患者之间没有相关性。高淋巴细胞和单核细胞计数与早期乳腺癌的低复发率相关，特别是在肥胖患者和报告饮酒的患者中。
To evaluate the relationship of circulating immune cells with recurrence and metabolic/lifestyle factors in patients with early stage breast cancer. Patients with early stage breast cancer were identified from the electronic record and institutional registry. Lymphocyte and monocyte counts were obtained from blood samples at time of diagnosis prior to any chemotherapy. Correlations between lymphocyte and monocyte and recurrence were assessed in the entire cohort and among obese patients, those reporting alcohol consumption, and smoking. Competing risk regression was used to analyze time to recurrence. A total of 950 patients with ≥5 years of follow-up were identified; 433 had complete data and were eligible for analysis. 293 (68%) had hormone receptor-positive breast cancer, 82 (19%) HER2 positive, and 53 (13%) triple negative. Patients in the highest quintile of lymphocytes compared to the lowest quintile had lower risk of recurrence (sub-hazard ratio (SHR)=0.17, 95% CI [0.03–0.93], p=0.041) while patients in the highest quintile of monocytes had lower risk for recurrence (SHR= 0.19, 95% CI [0.04, 0.92], p=0.039). Higher monocytes were more strongly associated with lower recurrence among those reporting alcohol consumption (HR= 0.10, 95% CI [0.01, 0.91], p=0.04). In obese patients, higher lymphocytes were associated with lower risk of recurrence (p=0.046); in non-obese patients, higher monocytes were associated with lower risk of recurrence (p=0.02). There were no correlations among patients who reported tobacco use. High lymphocyte and monocyte counts are associated with lower recurrence rate in early stage breast cancer, particularly in obese patients and those reporting alcohol consumption.
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影响因子：
4.6
作者：
Yeap WH;Wong KL;Shimasaki N;Teo EC;Quek JK;Yong HX;Diong CP;Bertoletti A;Linn YC;Wong SC
通讯作者：
Wong SC
DOI：
10.1158/1078-0432.ccr-17-1323
发表时间：
2018-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Afghahi A;Purington N;Han SS;Desai M;Pierson E;Mathur MB;Seto T;Thompson CA;Rigdon J;Telli ML;Badve SS;Curtis CN;West RB;Horst K;Gomez SL;Ford JM;Sledge GW;Kurian AW
通讯作者：
Kurian AW
影响因子：
3.8
作者：
Araki K;Ito Y;Fukada I;Kobayashi K;Miyagawa Y;Imamura M;Kira A;Takatsuka Y;Egawa C;Suwa H;Ohno S;Miyoshi Y
通讯作者：
Miyoshi Y
影响因子：
45.3
作者：
Kwan, Marilyn L.;Kushi, Lawrence H.;Caan, Bette J.
通讯作者：
Caan, Bette J.
影响因子：
4.8
作者：
Saha, Banishree;Momen-Heravi, Fatemeh;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi