T cells, murine chronic graft-versus-host disease and autoimmunity.
T cells, murine chronic graft-versus-host disease and autoimmunity.
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DOI：
10.1016/j.jaut.2012.05.017
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发表时间：
2012-09
影响因子：
12.8
通讯作者：
Via CS
中科院分区：
文献类型：
--
作者：
Eisenberg RA;Via CS
小鼠慢性移植物抗宿主病（cGVHD）的特征在于产生系统性红斑狼疮（狼疮）的自身抗体和免疫病理学特征。其基本发病机制涉及来自供体的同种异体反应性CD 4 T细胞对宿主B细胞的外来MHC II类的同源识别。在转移供体T细胞之前，宿主的CD 4 T细胞对于宿主B细胞的完全成熟也是必需的。CD 8 T细胞也发挥着重要作用。具有高度细胞毒性的供体CD 8 T细胞可以部分通过杀死受体B细胞来消除或预防狼疮综合征。宿主CD 8 T细胞可以下调供体CD 8 T细胞，从而阻止它们抑制自身免疫过程。因此，当供体接种物含有CD 4 T细胞和CD 8 T细胞时，所产生的综合征取决于这些不同细胞群的活性平衡。例如，在一个cGVHD模型（DBA/2（C57 BL/6xDBA/2）F1）中，该疾病在雌性中更严重，因为它在几种自发性狼疮小鼠模型以及人类疾病中也是如此。这种女性疾病倾向的机制似乎取决于女性宿主的CD 8细胞相对不能下调驱动自身抗体应答的供体CD 4 T细胞。一般来说，cGVHD中观察到的异常CD 4 T细胞帮助和CD 8 T细胞的调节作用与小鼠和人类狼疮中T细胞参与遗传性狼疮平行，尽管这些自发性综合征可能不是由明显的同种异体反应性驱动的。
The chronic graft-versus-host disease (cGVHD) in mice is characterized by the production of autoantibodies and immunopathology characteristic of systemic lupus erythematosus (lupus). The basic pathogenesis involves the cognate recognition of foreign MHC class II of host B cells by alloreactive CD4 T cells from the donor. CD4 T cells of the host are also necessary for the full maturation of host B cells before the transfer of donor T cells. CD8 T cells play critical roles as well. Donor CD8 T cells that are highly cytotoxic can ablate or prevent the lupus syndrome, in part by killing recipient B cells. Host CD8 T cells can reciprocally downregulate donor CD8 T cells, and thus prevent them from suppressing the autoimmune process. Thus, when the donor inoculum contains both CD4 T cells and CD8 T cells, the resultant syndrome depends on the balance of activities of these various cell populations. For example, in one cGVHD model (DBA/2 (C57BL/6xDBA/2)F1, the disease is more severe in females, as it is in several of the spontaneous mouse models of lupus, as well as in human disease. The mechanism of this female skewing of disease appears to depend on the relative inability of CD8 cells of the female host to downregulate the donor CD4 T cells that drive the autoantibody response. In general, then, the abnormal CD4 T cell help and the modulating roles of CD8 T cells seen in cGVHD parallel the participation of T cells in genetic lupus in mice and human lupus, although these spontaneous syndromes are presumably not driven by overt alloreactivity.
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DOI：
10.1016/j.clim.2010.01.005
发表时间：
2010-07
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Foster AD;Haas M;Puliaeva I;Soloviova K;Puliaev R;Via CS
通讯作者：
Via CS
影响因子：
6.2
作者：
LAFUSE, WP;MCCORMICK, JF;DAVID, CS
通讯作者：
DAVID, CS
影响因子：
15.9
作者：
Busser, BW;Adalr, BS;Laufer, TM
通讯作者：
Laufer, TM
影响因子：
4.4
作者：
Choudhury, A;Maldonado, MA;Eisenberg, RA
通讯作者：
Eisenberg, RA
影响因子：
5.5
作者：
Leonard, Warren J.;Zeng, Rong;Spolski, Rosanne
通讯作者：
Spolski, Rosanne