pH-Responsive Polymer Nanomaterials for Tumor Therapy.
pH-Responsive Polymer Nanomaterials for Tumor Therapy.
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DOI：
10.3389/fonc.2022.855019
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发表时间：
2022
影响因子：
4.7
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Chu S;Shi X;Tian Y;Gao F
肿瘤微环境的复杂性对癌症治疗提出了重大挑战，同时也为靶向给药提供了机会。利用肿瘤微环境的特征信号，可以构建各种刺激响应型药物递送系统，从而将药物定向递送到肿瘤部位。其中，由于肿瘤微环境的pH值低于血液和健康组织的pH值，因此经常使用pH值。PH响应型聚合物载体可以提高体内给药效率，实现靶向给药，减少药物不良反应，实现多功能和个性化治疗。PH响应型聚合物因其优越的性质和在肿瘤治疗中的应用潜力而受到越来越多的关注。本文综述了pH响应型聚合物纳米材料在癌症治疗中的最新进展和常见应用，重点介绍了不同类型的pH响应型聚合物。并对该领域面临的挑战和应用前景进行了展望。
The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery systems can be constructed for targeted drug delivery to tumor sites. Among these, the pH is frequently utilized, owing to the pH of the tumor microenvironment being lower than that of blood and healthy tissues. pH-responsive polymer carriers can improve the efficiency of drug delivery in vivo, allow targeted drug delivery, and reduce adverse drug reactions, enabling multifunctional and personalized treatment. pH-responsive polymers have gained increasing interest due to their advantageous properties and potential for applicability in tumor therapy. In this review, recent advances in, and common applications of, pH-responsive polymer nanomaterials for drug delivery in cancer therapy are summarized, with a focus on the different types of pH-responsive polymers. Moreover, the challenges and future applications in this field are prospected.
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影响因子：
6.7
作者：
Abd-Alla HI;Souguir D;Radwan MO
通讯作者：
Radwan MO
DOI：
10.1016/j.jconrel.2015.04.031
发表时间：
2015-07-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Camacho KM;Kumar S;Menegatti S;Vogus DR;Anselmo AC;Mitragotri S
通讯作者：
Mitragotri S
影响因子：
2.5
作者：
Chen, Daquan;Song, Xiaoyan;Zhao, Feng
通讯作者：
Zhao, Feng
影响因子：
16.6
作者：
Dan, Krishna;Ghosh, Suhrit
通讯作者：
Ghosh, Suhrit
紫杉醇的pH依赖性控制的低剂量释放的聚合物胶束。
影响因子：
14
作者：
Alani, Adam W. G.;Bae, Younsoo;Rao, Deepa A.;Kwon, Glen S.
通讯作者：
Kwon, Glen S.