High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study.
High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study.
复制标题
DOI：
10.1038/s41430-021-00859-9
复制
发表时间：
2021-10
影响因子：
4.7
通讯作者：
Ishida M
中科院分区：
文献类型：
--
作者：
Onishi H;Sato I;Uchida N;Takahashi T;Furuya D;Ebihara Y;Yoshioka A;Ito H;Ishida M
最近的研究表明，硫胺素缺乏（TD）是癌症患者出现谵妄的一个原因。然而，韦尼克脑病的存在程度以及患者的具体情况尚不清楚。在这项回顾性描述性研究中，我们调查了被心理肿瘤学家诊断为谵妄的癌症患者，以阐明 TD 的比例、硫胺素给药的治疗效果以及其发生的相关因素。在 71 名被心理肿瘤学家诊断为谵妄的患者中，45% 的患者发现了 TD。静脉注射硫胺素使大约 60% 的患者康复。我们使用带有马尔可夫链蒙特卡罗插补程序的多变量回归模型探讨了与 TD 相关的因素。我们发现 TD 和化疗之间存在关联（调整后的比值比，1.98 [95% 置信区间，1.04–3.77]）；然而，TD 与我们考虑的其他因素之间没有显着关联。 TD 在接受精神病咨询的谵妄患者中并不特别罕见。超过一半的患者通过静脉注射硫胺素缓解了谵妄。肿瘤学家应将 TD 视为癌症患者谵妄的一个原因。需要进一步的前瞻性研究来阐明癌症患者 TD 与谵妄之间的关系。
Recent studies have revealed thiamine deficiency (TD) as a cause of delirium in cancer patients. However, the extent to which Wernicke encephalopathy is present and in what patients is not well understood. In this retrospective descriptive study, we investigated referred cancer patients who were diagnosed with delirium by a psycho-oncologist to clarify the proportion of TD, the therapeutic effect of thiamine administration, and the factors involved in its onset. Among 71 patients diagnosed with delirium by a psycho-oncologist, TD was found in 45% of the patients. Intravenous administration of thiamine led to a recovery in about 60% of these patients. We explored the factors associated with TD using a multivariable regression model with a Markov chain Monte Carlo imputation procedure. We found an association between TD and chemotherapy (adjusted odds ratio, 1.98 [95% confidence interval, 1.04–3.77]); however, there were no significant associations between TD and the other factors we considered. TD is not particularly rare in delirium patients undergoing psychiatric consultation. The delirium was resolved in more than half of these patients by intravenous administration of thiamine. Oncologists should consider TD as a cause of delirium in cancer patients. Further prospective study is needed to clarify the relationship between TD and delirium in cancer patients.
登录
查看更多内容
影响因子：
3.4
作者：
Isenberg-Grzeda E;Alici Y;Hatzoglou V;Nelson C;Breitbart W
通讯作者：
Breitbart W
影响因子：
8.4
作者：
AKSOY, M;BASU, TK;DICKERSON, JWT
通讯作者：
DICKERSON, JWT
影响因子：
3.6
作者：
Isenberg-Grzeda, Elie;Shen, Megan Johnson;Alici, Yesne;Wills, Jonathan;Nelson, Christian;Breitbart, William
通讯作者：
Breitbart, William
影响因子：
2.2
作者：
Onishi, Hideki;Sugimasa, Yukio;Onose, Masanari
通讯作者：
Onose, Masanari
影响因子：
--
作者：
Inouye, SK;Foreman, MD;Cooney, LM
通讯作者：
Cooney, LM