HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC.
HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC.
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DOI：
10.1155/2017/3680305
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发表时间：
2017
影响因子：
--
通讯作者：
Qu L
中科院分区：
文献类型：
--
作者：
Sun C;Han C;Wang P;Jin Y;Sun Y;Qu L
本研究旨在探讨HOX基因在喉鳞状细胞癌（LSCC）中的表达谱，并探讨其与喉鳞状细胞癌临床病理特征及预后的关系。HOX基因水平通过微阵列检测，并通过qRT-PCR验证配对癌组织和相邻的非癌LSCC组织样本。39个HOX基因的微阵列测试数据显示，15个HOX基因至少上调2倍，2个基因下调。在qRT-PCR评估后，选择三种最上调的基因（HOXB 9、HOXB 13和HOXD 13）用于组织微阵列（TMA）分析。分析HOXB 9、HOXB 13和HOXD 13表达水平与临床病理特征和预后的相关性。3种HOX基因在喉鳞状细胞癌中的表达均明显高于癌旁组织（P < 0.001）。HOXB 9的表达与喉鳞癌的组织学分级和预后有关（P <0.01）。总之，本研究揭示HOXB 9、HOXB 13和HOXD 13在喉鳞状细胞癌中表达上调，可能在喉鳞状细胞癌中发挥重要作用。此外，HOXB 9可能作为一种新的预后不良的标志物和潜在的治疗靶点在喉鳞癌患者。
The purpose of this study was to investigate the HOX gene expression profile in laryngeal squamous cell carcinoma (LSCC) and assess whether some genes are associated with the clinicopathological features and prognosis in LSCC patients. The HOX gene levels were tested by microarray and validated by qRT-PCR in paired cancerous and adjacent noncancerous LSCC tissue samples. The microarray testing data of 39 HOX genes revealed 15 HOX genes that were at least 2-fold upregulated and 2 that were downregulated. After qRT-PCR evaluation, the three most upregulated genes (HOXB9, HOXB13, and HOXD13) were selected for tissue microarray (TMA) analysis. The correlations between the HOXB9, HOXB13, and HOXD13 expression levels and both clinicopathological features and prognosis were analyzed. Three HOX gene expression levels were markedly increased in LSCC tissues compared with adjacent noncancerous tissues (P < 0.001). HOXB9 was found to correlate with histological grade (P < 0.01) and prognosis (P < 0.01) in LSCC. In conclusion, this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in LSCC. Moreover, HOXB9 may serve as a novel marker of poor prognosis and a potential therapeutic target in LSCC patients.
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DOI：
10.1056/nejmoa1110000
发表时间：
2012-01-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ewing CM;Ray AM;Lange EM;Zuhlke KA;Robbins CM;Tembe WD;Wiley KE;Isaacs SD;Johng D;Wang Y;Bizon C;Yan G;Gielzak M;Partin AW;Shanmugam V;Izatt T;Sinari S;Craig DW;Zheng SL;Walsh PC;Montie JE;Xu J;Carpten JD;Isaacs WB;Cooney KA
通讯作者：
Cooney KA
影响因子：
1.7
作者：
Chu, Eugene A.;Kim, Young J.
通讯作者：
Kim, Young J.
影响因子：
2.6
作者：
Hardisson, D
通讯作者：
Hardisson, D
影响因子：
6.4
作者：
Maeda, K;Hamada, J;Moriuchi, T
通讯作者：
Moriuchi, T
影响因子：
7.4
作者：
Lewis, MT
通讯作者：
Lewis, MT