Early life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signaling.
Early life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signaling.
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DOI：
10.1016/j.neuroscience.2009.05.029
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发表时间：
2009-09-15
期刊：
影响因子：
3.3
通讯作者：
Bale, T. L.
中科院分区：
文献类型：
--
作者：
Teegarden, S. L.;Scott, A. N.;Bale, T. L.
美国的超重和肥胖症继续以流行率增长，这在很大程度上是由于过度消费热量密集的美味食物。确定影响长期常量营养素偏好的因素可能会阐明预防和行为矫正的要点。在我们目前的研究中，我们研究了成年小鼠在出生后第三周急性暴露于高脂肪饮食的常量营养素偏好。我们假设在生命早期食用高脂肪饮食会改变成年饮食偏好中重要的中枢通路的编程。作为成年人，与对照组相比，早期暴露的小鼠显示出对高脂肪饮食的明显偏好。这种影响不是由于饮食熟悉，因为在同一早期阶段暴露于新型高碳水化合物饮食的小鼠未能表现出成年后大量营养素偏好的差异。在早期暴露的小鼠中，高脂肪饮食摄入量的增加是特定于饮食偏好的，因为未检测到总热量摄入或热量效率的变化。从机制上讲，在生命早期暴露于高脂肪饮食的小鼠表现出丘脑核中多巴胺信号传导的生化标志物的显著改变，包括磷酸化DARPP-32 Thr-75，ΔFosB和Cdk 5水平的变化。这些结果支持了我们的假设，即即使是短暂的早期生活暴露于高热量的美味饮食，也会改变饮食偏好和奖励中重要的中枢机制的长期编程。这些变化可能是导致西方世界体重增加的高脂肪食物被动过度消费的基础。
Overweight and obesity in the United States continues to grow at epidemic rates in large part due to the over consumption of calorically-dense palatable foods. Identification of factors influencing long-term macronutrient preferences may elucidate points of prevention and behavioral modification. In our current study, we examined the adult macronutrient preferences of mice acutely exposed to a high fat diet during the third postnatal week. We hypothesized that the consumption of a high fat diet during early life would alter the programming of central pathways important in adult dietary preferences. As adults, the early exposed mice displayed a significant preference for a diet high in fat compared to controls. This effect was not due to diet familiarity as mice exposed to a novel high carbohydrate diet during this same early period failed to show differences in macronutrient preferences as adults. The increased intake of high fat diet in early exposed mice was specific to dietary preferences as no changes were detected for total caloric intake or caloric efficiency. Mechanistically, mice exposed to a high fat diet during early life exhibited significant alterations in biochemical markers of dopamine signaling in the nucleus accumbens, including changes in levels of phospho-DARPP-32 Thr-75, ΔFosB, and Cdk5. These results support our hypothesis that even brief early life exposure to calorically-dense palatable diets alters long-term programming of central mechanisms important in dietary preferences and reward. These changes may underlie the passive overconsumption of high fat foods contributing to the increasing body mass in the Western world.
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DOI：
10.1073/pnas.1834271100
发表时间：
2003-09-02
影响因子：
11.1
作者：
Kolb, B;Gorny, G;Robinson, TE
通讯作者：
Robinson, TE
影响因子：
4.8
作者：
Bale, TL;Anderson, KR;Vale, WW
通讯作者：
Vale, WW
影响因子：
--
作者：
Ahima, RS;Hileman, SM
通讯作者：
Hileman, SM
影响因子：
2.9
作者：
Leibowitz, SF;Sepiashvili, K;Chang, GQ
通讯作者：
Chang, GQ
影响因子：
25
作者：
Horvath, TL
通讯作者：
Horvath, TL