Commensal microbes and p53 in cancer progression.
Commensal microbes and p53 in cancer progression.
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DOI：
10.1186/s13062-020-00281-4
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发表时间：
2020-11-19
期刊：
影响因子：
5.5
通讯作者：
Amelio I
中科院分区：
文献类型：
--
作者：
Celardo I;Melino G;Amelio I
Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a number of reported correlative and causative links implicating alterations of commensal microbes in tumorigenesis. Bacteria appear to have the potential to directly alter physiological pathways of host cells and in specific circumstances, such as the mutation of the tumour suppressive factor p53, they can also directly switch the function of a gene from oncosuppressive to oncogenic. In this minireview, we report a number of examples on how commensal microbes alter the host cell biology, affecting the oncogenic process. We then discuss more in detail how interaction with the gut microbiome can affect the function of p53 mutant in the intestinal tumorigenesis.
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DOI：
10.1073/pnas.1808314115
发表时间：
2018-11-13
影响因子：
11.1
作者：
Amelio I;Mancini M;Petrova V;Cairns RA;Vikhreva P;Nicolai S;Marini A;Antonov AA;Le Quesne J;Baena Acevedo JD;Dudek K;Sozzi G;Pastorino U;Knight RA;Mak TW;Melino G
通讯作者：
Melino G
影响因子：
9
作者：
通讯作者：
--
影响因子：
23.4
作者：
Derosa, Lisa;Routy, Bertrand;Zitvogel, Laurence
通讯作者：
Zitvogel, Laurence
影响因子：
64.5
作者：
ELDEIRY, WS;TOKINO, T;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
7
作者：
Gao, Ce;Zhao, Di;Che, Jianhua
通讯作者：
Che, Jianhua