Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling.
Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling.
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雄性小鼠的急性和神经性疼痛模型中的十字酚介导的抗伤害感受和抗差异：耐受性和受体分析。
DOI：
10.3389/fphar.2022.968976
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发表时间：
2022
影响因子：
5.6
通讯作者：
Henderson-Redmond, Angela N.
中科院分区：
文献类型：
--
作者：
Crawford, LaTaijah C.;Kim, Sangyub;Karelia, Deepkamal;Sepulveda, Diana E.;Morgan, Daniel J.;Lu, Junxuan;Henderson-Redmond, Angela N.
韩国科学家已经证明，口服当归根部乙醇提取物及其吡喃香豆素的代谢物十香草醇，在各种热性和急性炎症性疼痛模型中具有抗伤害性。本研究的目的是：1)评估在急性热痛模型中，每天一次给予一次地高辛醇(50 mg/kg)是否对其产生耐受性；2)在化疗诱导的神经病理性疼痛(CENP)模型中，建立其抗痛觉过敏性效应和潜在的耐受性发展；3)探讨选择性受体参与拮抗剂的镇痛作用。结果表明，在热板法和甩尾法中，钩吻素醇均能产生抗伤害性感觉，并能逆转顺铂诱发的神经病理性疼痛小鼠的机械性超敏反应。在小鼠热板法和甩尾法中观察到了对秋水仙素的耐受性，对神经性变态反应小鼠表现出了对秋水仙素的抗痛觉过敏作用。在甩尾实验中，5-HT2受体拮抗剂甲基丝氨酸甲酯、5-HT2受体拮抗剂Volinanserin或5-HT2C受体拮抗剂SB-242084均不能减弱去甲肾上腺素的抗伤害性作用。预先给予大麻素反向激动剂利莫那班和SR144528均不能拮抗地高辛醇引起的痛觉异常，而阿片类拮抗剂纳洛酮可部分减弱地高辛醇的抗异位痛觉作用。综上所述，我们的数据支持十二醇是AGN的一种活性植物化学物质，具有抗伤害性和抗痛觉过敏性。未来的工作需要对潜在的受体机制进行更关键的研究，因为它们可能比最初报道的更复杂。
Korean scientists have shown that oral administration of Angelica gigas Nakai (AGN) root alcoholic extract and the metabolite of its pyranocoumarins, decursinol, have antinociceptive properties across various thermal and acute inflammatory pain models. The objectives of this study were 1) to assess whether tolerance develops to the antinociceptive effects of once-daily intraperitoneally administered decursinol (50 mg/kg) in acute thermal pain models, 2) to establish its anti-allodynic efficacy and potential tolerance development in a model of chemotherapy-evoked neuropathic pain (CENP) and 3) to probe the involvement of select receptors in mediating the pain-relieving effects with antagonists. The results show that decursinol induced antinociception in both the hot plate and tail-flick assays and reversed mechanical allodynia in mice with cisplatin-evoked neuropathic pain. Tolerance was detected to the antinociceptive effects of decursinol in the hot plate and tail-flick assays and to the anti-allodynic effects of decursinol in neuropathic mice. Pretreatment with either the 5-HT2 antagonist methysergide, the 5-HT2A antagonist volinanserin, or the 5-HT2C antagonist SB-242084 failed to attenuate decursinol-induced antinociception in the tail-flick assay. While pretreatment with the cannabinoid inverse agonists rimonabant and SR144528 failed to modify decursinol-induced anti-allodynia, pretreatment with the opioid antagonist naloxone partially attenuated the anti-allodynic effects of decursinol. In conclusion, our data support decursinol as an active phytochemical of AGN having both antinociceptive and anti-allodynic properties. Future work warrants a more critical investigation of potential receptor mechanisms as they are likely more complicated than initially reported.
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影响因子：
5
作者：
Henderson-Redmond AN;Crawford LC;Sepulveda DE;Hale DE;Lesperance JJ;Morgan DJ
通讯作者：
Morgan DJ
影响因子：
3.3
作者：
Guindon J;Deng L;Fan B;Wager-Miller J;Hohmann AG
通讯作者：
Hohmann AG
影响因子：
5.1
作者：
Kang, SY;Lee, KY;Kim, YC
通讯作者：
Kim, YC
影响因子：
7.4
作者：
Jiang, Cheng;Guo, Junming;Lu, Junxuan
通讯作者：
Lu, Junxuan
影响因子：
7.4
作者：
Bardin, L;Lavarenne, J;Eschalier, A
通讯作者：
Eschalier, A