Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception.
Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception.
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DOI：
10.1038/s41593-017-0005-0
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发表时间：
2017-12
影响因子：
25
通讯作者：
Gallio M
中科院分区：
文献类型：
--
作者：
Arenas OM;Zaharieva EE;Para A;Vásquez-Doorman C;Petersen CP;Gallio M
All animals must detect noxious stimuli to initiate protective behavior, but the evolutionary origin of nociceptive systems is not well understood. Here, we show that noxious heat and irritant chemicals elicit robust escape behaviors in the planarian Schmidtea mediterranea, and that the conserved ion channel TRPA1 is required for these responses. TRPA1 mutant flies (Drosophila) are also defective in noxious heat responses. Unexpectedly, we find that either planarian or human TRPA1 can restore noxious heat avoidance to TRPA1 mutant Drosophila, even though neither is directly activated by heat. Instead, our data suggest that TRPA1 activation is mediated by H2O2/Reactive Oxygen Species, early markers of tissue damage rapidly produced as a result of heat exposure. Together, our data reveal a core function for TRPA1 in noxious heat transduction, demonstrate its conservation from planarians to humans, and imply that animal nociceptive systems may share a common ancestry, tracing back to a progenitor that lived more than 500 million years ago.
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影响因子：
16.6
作者：
Chen, Jun;Kang, Dawon;Xu, Jing;Lake, Marc;Hogan, James O.;Sun, Chaohong;Walter, Karl;Yao, Betty;Kim, Donghee
通讯作者：
Kim, Donghee
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1523/jneurosci.5369-07.2008
发表时间：
2008-03-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andersson DA;Gentry C;Moss S;Bevan S
通讯作者：
Bevan S
影响因子：
7.7
作者：
Du, Eun Jo;Ahn, Tae Jung;Kang, KyeongJin
通讯作者：
Kang, KyeongJin
影响因子：
16.2
作者：
Kwan, KY;Allchorne, AJ;Corey, DP
通讯作者：
Corey, DP