Black Ginger (Kaempferia parviflora) Extract Enhances Endurance Capacity by Improving Energy Metabolism and Substrate Utilization in Mice.
Black Ginger (Kaempferia parviflora) Extract Enhances Endurance Capacity by Improving Energy Metabolism and Substrate Utilization in Mice.
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DOI：
10.3390/nu14183845
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发表时间：
2022-09-17
期刊：
影响因子：
5.9
通讯作者：
Suzuki K
中科院分区：
文献类型：
--
作者：
Huang J;Tagawa T;Ma S;Suzuki K
黑姜（Kaempferia parviflora）提取物（KPE），从生长在泰国的生姜家族成员KP中提取，对细胞能量代谢具有良好的促进作用，因此在先前的研究中已被用于增强运动表现和治疗肥胖。然而，KPE单次给药对耐力的影响尚未得到深入研究，KPE对细胞能量代谢的积极作用是否能在单次给药中对运动能力产生积极影响尚不清楚。在本研究中，我们使用小鼠模型来研究运动前1小时急性给予KPE对耐力的影响及其机制。我们研究的目的是确定KPE单次给药是否会影响小鼠的耐力表现，以及这种影响是否是通过促细胞能量代谢途径产生的。结果表明，单次服用KPE（62.5mg/kg·bodyweight）可显著延长运动至力竭时间。通过测定骨骼肌和肝脏中Hk2、Slc2a4（Glut4）、Mct 1、Ldh、Cd36、Cpt 1 β、Cpt 2、Lpl、Pnpla2（Atgl）、Aco、Acadm（Mcad）、Hadh、Acacb（Acc2）、Mlycd（Mcd）、Pparg、Ppargc1a（Pgc-1 α）、Tfam、Gp、Gs、Pfkm、Pck1（Pepck）、G6pc（G6pase）、Cs和Pfkl的mRNA表达，我们发现，急性高浓度KPE给药显著改变了比目鱼肌基因表达水平（p <0.05），这些基因表达水平与脂质、乳酸和糖原代谢以及线粒体功能有关。在腓肠肌和肝脏中，糖原代谢相关基因的表达被单剂量给予KPE显著改变。这些结果表明，KPE有可能通过提高肌肉和肝脏的能量代谢和底物利用来提高耐力。
Black ginger (Kaempferia parviflora) extract (KPE), extracted from KP, a member of the ginger family that grows in Thailand, has a good promotion effect on cellular energy metabolism and therefore has been used to enhance exercise performance and treatment of obesity in previous studies. However, the effect of single-dose administration of KPE on endurance capacity has not been thoroughly studied, and whether the positive effect of KPE on cellular energy metabolism can have a positive effect on exercise capacity in a single dose is unknown. In the present study, we used a mouse model to study the effects of acute KPE administration 1 h before exercise on endurance capacity and the underlying mechanisms. The purpose of our study was to determine whether a single administration of KPE could affect endurance performance in mice and whether the effect was produced through a pro-cellular energy metabolic pathway. We found that a single administration of KPE (62.5 mg/kg·bodyweight) can significantly prolong the exercise time to exhaustion. By measuring the mRNA expression of Hk2, Slc2a4 (Glut4), Mct1, Ldh, Cd36, Cpt1β, Cpt2, Lpl, Pnpla2 (Atgl), Aco, Acadm (Mcad), Hadh, Acacb (Acc2), Mlycd (Mcd), Pparg, Ppargc1a (Pgc-1α), Tfam, Gp, Gs, Pfkm, Pck1 (Pepck), G6pc (G6pase), Cs, and Pfkl in skeletal muscle and liver, we found that acute high-concentration KPE administration significantly changed the soleus muscle gene expression levels (p < 0.05) related to lipid, lactate, and glycogen metabolism and mitochondrial function. In gastrocnemius muscle and liver, glycogen metabolism-related gene expression is significantly changed by a single-dose administration of KPE. These results suggest that KPE has the potential to improve endurance capacity by enhancing energy metabolism and substrate utilization in muscles and liver.
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DOI：
10.1152/ajpendo.00312.2005
发表时间：
2006-03-01
影响因子：
5.1
作者：
Bezaire, V;Bruce, CR;Spriet, LL
通讯作者：
Spriet, LL
影响因子：
3.3
作者：
Jeong, J.;Kwon, E. G.;Baik, M.
通讯作者：
Baik, M.
影响因子：
2.5
作者：
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通讯作者：
Westerblad, Hakan
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影响因子：
5.8
作者：
Hu, Chunxiu;Hoene, Miriam;Weigert, Cora
通讯作者：
Weigert, Cora
影响因子：
5.9
作者：
Hearris MA;Hammond KM;Fell JM;Morton JP
通讯作者：
Morton JP