Teaching old mice new tricks: the utility of aged mouse models of C. difficile infection to study pathogenesis and rejuvenate immune response.
Teaching old mice new tricks: the utility of aged mouse models of C. difficile infection to study pathogenesis and rejuvenate immune response.
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DOI：
10.1080/19490976.2021.1966255
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
Warren CA
中科院分区：
文献类型：
--
作者：
Shin JH;Pawlowski SW;Warren CA
艰难梭状芽胞杆菌是老龄化人口面临的严重问题。艰难梭菌感染(CDI)衰老小鼠模型已成为评价CDI衰老机制的有价值的工具。我们回顾了五项已发表的利用老龄小鼠(7-28个月)进行CDI模型的研究，以期发现可能会促进我们对衰老如何影响CDI结果的理解。CDI的老年小鼠模型一致显示，与年轻小鼠相比，老年小鼠的疾病更严重。中性粒细胞在老年小鼠肠道组织中的募集减少是最一致的发现。先天免疫反应和体液免疫反应的差异也被观察到。衰老对感染结果的影响可通过药物或微生物区系靶向干预而逆转。衰老小鼠是研究CDI的重要体内模型，并阐明了高龄是严重疾病的重要危险因素的机制。
Clostridioides difficile is a serious problem for the aging population. Aged mouse model of C. difficile infection (CDI) has emerged as a valuable tool to evaluate the mechanism of aging in CDI. We reviewed five published studies utilizing aged mice (7–28 months) for CDI model for findings that may advance our understanding of how aging influences outcome from CDI. Aged mouse models of CDI uniformly demonstrated more severe disease in the old compared to young mice. Diminished neutrophil recruitment to intestinal tissue in aged mice is the most consistent finding. Differences in innate and humoral immune responses were also observed. The effects of aging on the outcome of infection were reversed by pharmacologic or microbiota-targeted interventions. The aged mouse presents an important in vivo model to study CDI and elucidate the mechanisms underlying advanced age as an important risk factor for severe disease.
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