Modifiable early life exposures associated with adiposity and obesity in 3-year old children born to mothers with obesity.
Modifiable early life exposures associated with adiposity and obesity in 3-year old children born to mothers with obesity.
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DOI：
10.1111/ijpo.12801
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发表时间：
2021-11
影响因子：
3.8
通讯作者：
UPBEAT Consortium
中科院分区：
文献类型：
--
作者：
Dalrymple KV;Flynn AC;Seed PT;Briley AL;O'Keeffe M;Godfrey KM;Poston L;UPBEAT Consortium
肥胖母亲所生的孩子患肥胖症的风险更高。这种易感性的潜在影响包括宫内暴露、遗传易感性和共同的家庭环境。需要有效的干预策略来预防这些高危儿童的肥胖；这需要评估可改变的怀孕和早期生命风险因素。评估母亲和早期生活可改变的暴露对肥胖妇女所生的3岁儿童的儿童肥胖和肥胖结局的个人和累积贡献。在495名3岁儿童中，我们使用调整回归来评估六种暴露(早期孕期BMI、孕期体重增加过多、婴儿喂养方式和儿童饮食习惯的三项指标(食物反应、进食缓慢和加工/零食饮食模式得分))对身体成分的个体和累积贡献。结果包括体重指数z评分、臂围和超重/肥胖(体重指数≥25.0 kg/m2)。虽然乐观的干预并没有影响3岁儿童的肥胖结果，但这六种可改变的暴露加在一起，逐渐增加了儿童的肥胖和肥胖。每增加一次暴露，儿童的体重指数z得分(β=0.35SD(95%可信区间：0.23，0.47))、臂围(β=0.59 cm(0.40，0.79))和超重/肥胖风险(相对风险1.49(1.26，1.77))都更高。与没有暴露的儿童相比，暴露于四次或更多暴露的儿童有更高的BMI z得分(1.11SD(0.65，1.58))、臂围(2.15 cm(1.41，2.89))和超重/肥胖风险(3.01(1.67，5.41))(均P<；0.001)。我们的发现表明，针对未孕、怀孕、围产期和儿童早期暴露的复杂干预措施为预防学龄前肥胖提供了一种潜在的策略。
Children born to mothers with obesity are at increased risk of obesity. Influences underlying this predisposition include in-utero exposures, genetic predisposition and a shared family environment. Effective intervention strategies are needed to prevent obesity in these high-risk children; this requires evaluation of modifiable pregnancy and early-life risk factors. To assess the individual and cumulative contributions of maternal and early-life modifiable exposures on childhood adiposity and obesity outcomes in 3-year-old children born to women with obesity. We used adjusted regression to assess the individual and cumulative contributions of six exposures (early pregnancy BMI, excessive gestational weight gain, mode of infant feeding and three measures of childhood eating habits (food responsiveness, slowness in eating and a processed/snacking dietary pattern score)) on body composition in 495 three-year-old children. Outcomes included BMI z-score, arm circumference and overweight/obesity (BMI≥25.0kg/m2). While the UPBEAT intervention did not influence adiposity outcomes in 3-year-old children, the six modifiable exposures combined incrementally to increase childhood adiposity and obesity. For each additional exposure, children had a higher BMI z-score (β=0.35SD (95% confidence interval: 0.23, 0.47)), arm circumference (β=0.59cm (0.40, 0.79)) and risk of overweight/obesity (relative risk 1.49 (1.26, 1.77)). Compared to no exposures, children with four or more exposures had a higher BMI z-score (1.11SD (0.65, 1.58)), arm circumference (2.15cm (1.41, 2.89)) and risk of overweight/obesity (3.01 (1.67, 5.41)) (all p<0.001). Our findings suggest that complex interventions targeting preconception, pregnancy, perinatal and early childhood exposures offer a potential strategy for prevention of pre-school obesity.
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DOI：
10.1177/1367493520917863
发表时间：
2021-06
期刊：
Journal of child health care : for professionals working with children in the hospital and community
影响因子：
--
作者：
Narzisi K;Simons J
通讯作者：
Simons J
DOI：
10.1017/s0007114517000848
发表时间：
2017-04
期刊：
The British journal of nutrition
影响因子：
--
作者：
Fogel A;Goh AT;Fries LR;Sadananthan SA;Velan SS;Michael N;Tint MT;Fortier MV;Chan MJ;Toh JY;Chong YS;Tan KH;Yap F;Shek LP;Meaney MJ;Broekman BFP;Lee YS;Godfrey KM;Chong MFF;Forde CG
通讯作者：
Forde CG
影响因子：
3.1
作者：
Briley AL;Barr S;Badger S;Bell R;Croker H;Godfrey KM;Holmes B;Kinnunen TI;Nelson SM;Oteng-Ntim E;Patel N;Robson SC;Sandall J;Sanders T;Sattar N;Seed PT;Wardle J;Poston L
通讯作者：
Poston L
影响因子：
2.8
作者：
Draper, C. E.;Bosire, E.;Norris, S. A.
通讯作者：
Norris, S. A.
影响因子：
7
作者：
Koletzko, Berthold;Brands, Brigitte;Demmelmair, Hans
通讯作者：
Demmelmair, Hans