Mammalian chromosomes contain cis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes.
Mammalian chromosomes contain cis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes.
复制标题
哺乳动物染色体含有顺式作用元件，可控制整个染色体的复制时间，有丝分裂凝结和稳定性。
DOI：
10.1002/bies.201200035
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发表时间：
2012-09
期刊：
影响因子：
4
通讯作者：
Thayer, Mathew J.
中科院分区：
文献类型：
--
作者：
Thayer, Mathew J.
Recent studies indicate that mammalian chromosomes contain discrete cis-acting loci that control replication timing, mitotic condensation and stability of entire chromosomes. Disruption of the large non-coding RNA gene ASAR6 results in late replication, an under-condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono-allelic expression and asynchronous replication timing. Additional ‘chromosome engineering’ studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain ‘inactivation/stability centers’ that control proper replication, condensation and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types of cis-acting elements, origins, telomeres centromeres, and ‘inactivation/stability centers’, all functioning to ensure proper replication, condensation, segregation and stability of individual chromosomes.
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作者：
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通讯作者：
Debatisse, M
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SPERLING K
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CLARKE, G
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通讯作者：
Pellman, David