Filovirus entry.

Filovirus entry.
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DOI:
10.1007/978-1-4614-7651-1_5
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发表时间:
2013
影响因子:
--
通讯作者:
Simmons G
Simmons G
中科院分区:
医学4区
文献类型:
--
作者:
Simmons G

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近年来的一些进展极大地加深了我们对丝状病毒附着和细胞趋向性的理解。例如,几种细胞表面分子已被确定为附着因子,具有促进特定细胞类型的体内靶向的潜力,如巨噬细胞和肝细胞。此外,我们对丝状病毒进入期间的内化和后续事件的知识也得到了扩大,为艾滋病毒和流感病毒进入所建立的范例增加了新的变化。特别是,宿主细胞因子,如内体蛋白酶和胞内受体Niemann-Pick C1,现在已被认为在激活丝状病毒糖蛋白的膜融合潜力方面发挥着至关重要的作用。
A number of advances in recent years have significantly furthered our understanding of filovirus attachment and cellular tropism. For example, several cell-surface molecules have been identified as attachment factors with the potential to facilitate the in vivo targeting of particular cell types such as macrophages and hepatic cells. Furthermore, our knowledge of internalization and subsequent events during filovirus entry has also been widened, adding new variations to the paradigms for viral entry established for HIV and influenza. In particular, host cell factors such as endosomal proteases and the intracellular receptor Niemann-Pick C1 are now known to play a vital role in activating the membrane fusion potential of filovirus glycoproteins.
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