Strong homology in promoter and 3′-untranslated regions of chick and rat α-actin genes
Strong homology in promoter and 3′-untranslated regions of chick and rat α-actin genes
复制标题
鸡和大鼠 α-肌动蛋白基因的启动子和 3-非翻译区具有很强的同源性
作者：
C. Ordahl;T. Cooper
本文报道鸡和大鼠骨骼肌α-肌动蛋白基因核苷酸序列的比较，发现在假定的转录启动子和3′-非翻译区存在高度保守的序列块。这是鸟类和哺乳动物之间的非翻译基因区域的强序列保守性的第一个实例，除了CAAT和ATA启动子同源性和推定的poly（A）添加信号AATAAA 1。这些序列的高度保守性表明它们可能在骨骼肌α-肌动蛋白基因的组织特异性表达中起作用。
We report here a comparison of the nucleotide sequences of the chick and rat skeletal muscle α-actin genes which reveals strongly conserved blocks of sequence in the putative transcriptional promoter and 3′-untranslated regions. This is the first instance of strong sequence conservation in untranslated gene regions between birds and mammals, other than the CAAT and ATA promoter homologies and the putative poly(A) addition signal, AATAAA1. The strong conservation of these sequences suggests that they may have a role in the tissue-specific expression of the skeletal muscle α-actin gene.
小鼠和中国仓鼠的次黄嘌呤鸟嘌呤磷酸核糖基转移酶基因：cDNA重组体的构建和序列分析。
影响因子：
14.9
作者：
Konecki,DS;Brennand,J;Fuscoe,JC;Caskey,CT;Chinault,AC
通讯作者：
Chinault,AC