Loud Music Exposure and Cochlear Synaptopathy in Young Adults: Isolated Auditory Brainstem Response Effects but No Perceptual Consequences.
Loud Music Exposure and Cochlear Synaptopathy in Young Adults: Isolated Auditory Brainstem Response Effects but No Perceptual Consequences.
复制标题
DOI：
10.1177/2331216517737417
复制
发表时间：
2017-01
影响因子：
2.7
通讯作者：
Hall JW 3rd
中科院分区：
文献类型：
--
作者：
Grose JH;Buss E;Hall JW 3rd
本研究的目的是检验这一假设，即经常暴露于响亮的音乐的听众表现出与耳蜗突触病一致的阈上听觉表现缺陷。招募了听力正常的年轻人，他们（n = 31）或（n = 30）有经常参加大声音乐场所的历史，典型的声级可能会导致暂时的阈值偏移。实施包括三组程序的测试组合：（a）电生理测试，包括畸变产物耳声发射、听觉脑干反应、包络跟随反应和由耳间相位反转诱发的声学变化复合体;（B）心理声学测试，包括时间调制检测、频谱调制检测和对耳间相位的敏感性;以及（c）语音测试，包括滤波音素识别和噪声中语音识别。结果表明，大声的音乐暴露的历史，可以导致一个配置文件的外周听觉功能，这是符合人类耳蜗突触病的解释，即中度异常的听觉脑干反应波I/波V的比例存在正常的畸变产物耳声发射和正常的听力阈值。然而，没有其他电生理学、心理物理学或言语感知效应。在阈上声音处理中没有任何行为效应表明，即使耳蜗突触病是人类有效的病理生理学条件，其感知后遗症要么过于分散，要么过于无关紧要，无法对隐藏的听力损失进行简单的鉴别诊断。
The purpose of this study was to test the hypothesis that listeners with frequent exposure to loud music exhibit deficits in suprathreshold auditory performance consistent with cochlear synaptopathy. Young adults with normal audiograms were recruited who either did (n = 31) or did not (n = 30) have a history of frequent attendance at loud music venues where the typical sound levels could be expected to result in temporary threshold shifts. A test battery was administered that comprised three sets of procedures: (a) electrophysiological tests including distortion product otoacoustic emissions, auditory brainstem responses, envelope following responses, and the acoustic change complex evoked by an interaural phase inversion; (b) psychoacoustic tests including temporal modulation detection, spectral modulation detection, and sensitivity to interaural phase; and (c) speech tests including filtered phoneme recognition and speech-in-noise recognition. The results demonstrated that a history of loud music exposure can lead to a profile of peripheral auditory function that is consistent with an interpretation of cochlear synaptopathy in humans, namely, modestly abnormal auditory brainstem response Wave I/Wave V ratios in the presence of normal distortion product otoacoustic emissions and normal audiometric thresholds. However, there were no other electrophysiological, psychophysical, or speech perception effects. The absence of any behavioral effects in suprathreshold sound processing indicated that, even if cochlear synaptopathy is a valid pathophysiological condition in humans, its perceptual sequelae are either too diffuse or too inconsequential to permit a simple differential diagnosis of hidden hearing loss.
登录
查看更多内容
影响因子：
3
作者：
Bharadwaj HM;Verhulst S;Shaheen L;Liberman MC;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG
影响因子：
3.7
作者：
Jensen JB;Lysaght AC;Liberman MC;Qvortrup K;Stankovic KM
通讯作者：
Stankovic KM
DOI：
10.1044/jshd.1103.181
发表时间：
1946-09-01
期刊：
JOURNAL OF SPEECH DISORDERS
影响因子：
--
作者：
Doerfler, Leo;Stewart, Kenneth
通讯作者：
Stewart, Kenneth
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
影响因子：
3.7
作者：
Liberman MC;Epstein MJ;Cleveland SS;Wang H;Maison SF
通讯作者：
Maison SF