Liver-Expressed Antimicrobial Peptide 2 Is a Hepatokine That Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus after Vertical Sleeve Gastrectomy in Japanese Individuals.
Liver-Expressed Antimicrobial Peptide 2 Is a Hepatokine That Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus after Vertical Sleeve Gastrectomy in Japanese Individuals.
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肝脏表达的抗菌肽2是一种肝因子，可预测日本人垂直袖状胃切除术后体重减轻和2型糖尿病完全缓解。
DOI：
10.1159/000530733
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发表时间：
2023
期刊：
影响因子：
3.6
通讯作者：
Nakazato M
中科院分区：
文献类型：
--
作者：
Nabekura H;Islam MN;Sakoda H;Yamaguchi T;Saiki A;Nabekura T;Oshiro T;Tanaka Y;Murayama S;Zhang W;Tatsuno I;Nakazato M
垂直袖状胃切除术（VSG）被认为是持续减肥和完全缓解2型糖尿病（CR-T2 DM）的最有效治疗方法之一。肝表达抗菌肽2（LEAP 2）是一种生长激素释放肽受体拮抗肽，是一种受VSG调节的代谢激素。然而，LEAP 2是否可以用于预测VSG的结果尚不清楚。本研究旨在评价LEAP 2作为VSG后体重减轻和CR-T2 DM的预测因素。这项回顾性研究包括39名接受VSG的日本肥胖受试者。在VSG之前和之后12个月研究了血清LEAP 2、去酰基生长素释放肽（DAG）和其他代谢和人体测量参数。生成受试者工作特征（ROC）曲线以评估体重减轻的预测评分，其临界值为> 50%过量体重减轻。还生成ROC曲线以评估CR-T2 DM。体重指数（BMI）为32-50 kg/m2的参与者的血清LEAP 2水平显著高于正常体重的参与者。BMI >50 kg/m2的参与者血清LEAP 2浓度低于BMI 32-50 kg/m2的参与者。VSG导致血清DAG浓度显著降低，但不影响男性或女性参与者的血清LEAP 2浓度。术前血清LEAP 2浓度为2.88 pmol/mL是预测VSG术后体重减轻的最佳临界值，其敏感性为80.0%，特异性为75.9%。术前血清LEAP 2水平高于4.67 pmol/mL预测VSG后CR-T2 DM的敏感性为100%，特异性为58.8%。术前血清LEAP 2水平可预测VSG后体重减轻和CR-T2 DM的发生。
Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a ghrelin receptor antagonist peptide, is a metabolic hormone regulated by VSG. However, it is unknown whether LEAP2 can be used to predict the outcomes of VSG. This study aimed to evaluate LEAP2 as a predictive factor for weight loss and CR-T2DM after VSG. This retrospective study included 39 Japanese participants with obesity who underwent VSG. Serum LEAP2, des-acyl ghrelin (DAG), and other metabolic and anthropometric parameters were studied before and at 12 months after VSG. Receiver operating characteristics (ROC) curve was generated to evaluate predictive score for weight loss with cut-off value of >50 percent excess weight loss. ROC curve was also generated to assess CR-T2DM. Serum LEAP2 levels were significantly higher in participants with body mass index (BMI) 32–50 kg/m2 than in those with normal weight. Participants with BMI >50 kg/m2 had lower serum LEAP2 concentrations than those with BMI 32–50 kg/m2. VSG caused a significant reduction in serum DAG concentrations, but it did not affect serum LEAP2 concentrations in either male or female participants. Preoperative serum LEAP2 concentration of 2.88 pmol/mL was the optimal cutoff value for predicting weight loss after VSG, with sensitivity of 80.0% and specificity of 75.9%. Preoperative serum LEAP2 level higher than 4.67 pmol/mL predicted CR-T2DM after VSG with sensitivity of 100% and specificity of 58.8%. Preoperative serum LEAP2 could predict weight loss and CR-T2DM as outcomes of VSG.
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影响因子：
16.6
作者：
Zaghlool SB;Sharma S;Molnar M;Matías-García PR;Elhadad MA;Waldenberger M;Peters A;Rathmann W;Graumann J;Gieger C;Grallert H;Suhre K
通讯作者：
Suhre K
影响因子：
2.2
作者：
Tadokoro, Rie;Iida, Tatsuya;Nagasaka, Shoichiro
通讯作者：
Nagasaka, Shoichiro
小鼠体内 LEAP2 缺失增强了 ghrelin 作为食欲原和生长激素促分泌素的作用。
影响因子：
8.1
作者：
Shankar K;Metzger NP;Singh O;Mani BK;Osborne-Lawrence S;Varshney S;Gupta D;Ogden SB;Takemi S;Richard CP;Nandy K;Liu C;Zigman JM
通讯作者：
Zigman JM
影响因子：
5.2
作者：
Mulla CM;Middelbeek RJW;Patti ME
通讯作者：
Patti ME
影响因子：
2.9
作者：
Aliakbarian, Hassan;Bhutta, Hina Y.;Tavakkoli, Ali
通讯作者：
Tavakkoli, Ali