Enhancement of HIV type 1 infectivity in vitro by capsular polysaccharide of Cryptococcus neoformans and Haemophilus influenzae.
Enhancement of HIV type 1 infectivity in vitro by capsular polysaccharide of Cryptococcus neoformans and Haemophilus influenzae.
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新型隐球菌和流感嗜血杆菌的荚膜多糖在体外增强 HIV 1 型感染性。
DOI：
10.1089/aid.1994.10.1079
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发表时间：
1994
影响因子：
1.5
通讯作者：
Goldstein,H
中科院分区：
文献类型：
--
作者：
Pettoello-Mantovani,M;Casadevall,A;Smarnworawong,P;Goldstein,H
High concentrations of the cryptococcal capsular polysaccharide (CCP) are present in the serum, cerebrospinal fluid or both in the majority of AIDS patients infected withCryptococcus neoformans. Because the prognosis of AIDS patients infected with cryptococcus is poor, we investigated whether the presence of CCP enhanced HIV-1 infection. The presence of CCP markedly increased the infectivity of HIV-1-infected H9 cells and subsequent production of infectious HIV-1 and formation of syncytia. In addition to enhancing the infectivity of H9 cells infected with laboratory isolates of HIV-1, the presence of CCP also increased the infectivity of peripheral blood mononuclear cells (PBMCs) infected with primary field strains of HIV-1. Thein vitroinfectivity of PBMCs from 20 of 44 HIV-1-infected individuals was significantly increased when cultured with CCP. Furthermore, HIV-1 was isolated from the PBMCs of three of these individuals only when cultured in the presence of CCP. CCP increased the binding of HIV-1 and recombinant gp120 to H9 cells and recombinant CD4, respectively. Thus, it is possible that the enhancement of HIV-1 infectivity by CCP is due to its capacity to increase the adherence of HIV-1 to target cells. Whereas the capsular polysaccharide ofHaemophilus influenzaealso markedly enhanced the infectivity of HIV-1, the capsular polysaccharides ofC. freundiiorS. flexnerihad minimal effects on the infectivity of HIV-1. This indicated that the capacity to enhance HIV-1 infectivity was a property of polysaccharides from some pathogens and not others. Because a high degree of HIV replication occurs in the lymph nodes during the latent phase of infection, the transport of CCP or HICP into the lymph nodes during the process of antigen presentation may inadvertently stimulate production of HIV-1 in infected cells and thereby accelerate the disease course.
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DOI：
10.1073/pnas.87.15.5817
发表时间：
1990
影响因子：
11.1
作者：
Graham,GJ;Maio,JJ
通讯作者：
Maio,JJ
HIV-1 包膜蛋白在杆状病毒感染的昆虫细胞中的时间表达：对糖基化和 CD4 结合的影响。
DOI：
10.1016/0735-0651(90)90030-j
发表时间：
1990
期刊：
Genetic analysis, techniques and applications
影响因子：
--
作者：
Murphy,CI;Lennick,M;Lehar,SM;Beltz,GA;Young,E
通讯作者：
Young,E
源自杆状病毒表达系统的重组 HIV-1 gp120 的位点特异性 N-糖基化和寡糖结构。
影响因子：
2.9
作者：
Yeh,JC;Seals,JR;Murphy,CI;vanHalbeek,H;Cummings,RD
通讯作者：
Cummings,RD
影响因子：
4.4
作者：
L. Rodrigues;R. Schneerson;J. Robbins
通讯作者：
J. Robbins
影响因子：
5.9
作者：
ENG, RHK;BISHBURG, E;KAPILA, R
通讯作者：
KAPILA, R