The coeliac stomach: gastritis in patients with coeliac disease.
The coeliac stomach: gastritis in patients with coeliac disease.
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DOI：
10.1111/apt.13249
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发表时间：
2015-07
影响因子：
7.6
通讯作者：
Genta RM
中科院分区：
文献类型：
--
作者：
Lebwohl B;Green PH;Genta RM
淋巴细胞性胃炎是一种少见的疾病，其症状和内镜表现各不相同。这个条件，以及两种形式的H。根据单中心研究，幽门阴性胃炎（慢性活动性胃炎[CAG]和慢性非活动性胃炎[CIG]）似乎在乳糜泻（CD）患者中更常见。比较十二指肠组织学正常（或非特异性肠炎）和CD（定义为绒毛萎缩）患者中LG、CAG和CIG的患病率（Marsh 3）。我们分析了六年期间提交给国家病理学实验室的所有同期胃和十二指肠活检标本。我们进行了多元逻辑回归，以确定每个胃炎亚型的独立预测因子。在同时进行胃和十二指肠活检的患者中（n= 287，503），平均年龄为52岁，大多数（67%）为女性。与十二指肠组织学正常的患者相比，LG更常见于部分绒毛萎缩（OR 37.66; 95% CI 30.16-47.03）和次全/全绒毛萎缩（OR 78.57; 95% CI 65.37-94.44）。CD在CAG中也更常见（部分绒毛萎缩的OR为1.93; 95%CI 1.49-2.51，次全/全绒毛萎缩的OR为2.42; 95%CI 1.90-3.09），与CIG相似（部分绒毛萎缩的OR为2.04; 95%CI 1.76-2.35，次全/全绒毛萎缩的OR为2.96; 95%CI 2.60-3.38）。LG与CD密切相关，患病率增加与更晚期的绒毛萎缩相关。CAG和CIG也与CD显著相关。未来的研究应该测量无麸质饮食治疗后这些疾病的自然史。
Lymphocytic gastritis (LG) is an uncommon entity with varying symptoms and endoscopic appearances. This condition, as well as two forms of H. pylori-negative gastritis (chronic active gastritis [CAG] and chronic inactive gastritis [CIG]), appears to be more common in patients with coeliac disease (CD) based on single-center studies. To compare the prevalence of LG, CAG, and CIG among those with normal duodenal histology (or non-specific duodenitis) and those with CD, as defined by villous atrophy (Marsh 3). We analyzed all concurrent gastric and duodenal biopsy specimens submitted to a national pathology laboratory during a six-year period. We performed multiple logistic regression to identify independent predictors of each gastritis subtype. Among patients who underwent concurrent gastric and duodenal biopsy (n=287,503), the mean age was 52 and the majority (67%) was female. Compared to patients with normal duodenal histology, LG was more common inpartial villous atrophy (OR 37.66; 95% CI 30.16–47.03), and subtotal/total villous atrophy (OR 78.57; 95% CI 65.37–94.44). CD was also more common in CAG (OR for partial villous atrophy 1.93; 95%CI 1.49–2.51, OR for subtotal/total villous atrophy 2.42; 95%CI 1.90–3.09) and was similarly associated with CIG (OR for partial villous atrophy 2.04; 95%CI 1.76–2.35, OR for subtotal/total villous atrophy 2.96; 95% CI 2.60–3.38). LG is strongly associated with CD, with increasing prevalence correlating with more advanced villous atrophy. CAG and CIG are also significantly associated with CD. Future researchshould measure the natural history of these conditions after treatment with a gluten-free diet.
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影响因子：
1.7
作者：
Freedberg DE;Lebwohl B;Abrams JA
通讯作者：
Abrams JA
DOI：
10.1016/j.giec.2012.07.001
发表时间：
2012-10-01
影响因子：
--
作者：
Bao, Fei;Bhagat, Govind
通讯作者：
Bhagat, Govind
影响因子：
24.5
作者：
HAOT, J;HAMICHI, L;MAINGUET, P
通讯作者：
MAINGUET, P
影响因子：
7.6
作者：
Genta, R. M.;Sonnenberg, A.
通讯作者：
Sonnenberg, A.
绒毛萎缩和腹腔血清学阴性：诊断和治疗的困境
影响因子：
9.8
作者：
DeGaetani, Marisa;Tennyson, Christina A.;Green, Peter H. R.
通讯作者：
Green, Peter H. R.