Lifestyle and diet as risk factors for overanticoagulation.
Lifestyle and diet as risk factors for overanticoagulation.
复制标题
生活方式和饮食是过度抗凝的危险因素。
DOI：
10.1016/s0895-4356(01)00485-1
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发表时间：
2002
影响因子：
7.2
通讯作者：
B. Stricker
中科院分区：
文献类型：
--
作者：
F. P. Penning;J. Geleijnse;E. van Meegen;C. Vermeer;F. Rosendaal;B. Stricker
当国际标准化比值（INR）> 6.0时，使用香豆素抗凝剂时出血的风险急剧增加。我们在抗凝门诊患者中进行了一项病例对照研究，以确定与过度抗凝相关的社会人口统计学、生活方式和饮食因素。将300例INR ≥ 6.0的病例与302例随机选择的INR在目标区域内的匹配对照进行比较。年龄、性别和教育水平与过度抗凝无关。体重指数与过度抗凝呈负相关，低于平均水平的体力活动与过度抗凝呈正相关，与吸烟者相比，从不吸烟者更可能有INR ≥ 6.0。习惯性饮酒，甚至大量饮酒，与过度抗凝无关。然而，最近酒精摄入量的减少增加了INR ≥ 6.0的风险。此外，体重减轻和度假是过度抗凝的危险因素。饮食因素与过度抗凝无关。如果无法避免危险因素，增加INR值的监测可以防止过度抗凝和潜在的出血并发症。
The risk of hemorrhage when using coumarin anticoagulants sharply increases when the International Normalized Ratio (INR) is ⩾6.0. We performed a case-control study among outpatients of an anticoagulation clinic to identify sociodemographic-, lifestyle-, and dietary factors related to overanticoagulation. Three hundred cases with an INR ⩾6.0 were compared with 302 randomly selected matched controls with an INR within the target zone. Age, sex, and level of education were not associated with overanticoagulation. Body mass index was negatively related to overanticoagulation, a beneath-average level of physical activity was positively related to overanticoagulation and never-smokers were more likely to have an INR ⩾6.0 compared with smokers. Habitual alcohol consumption, even heavy drinking, was not related to overanticoagulation. However, a recent decrease of alcohol intake increased the risk of an INR ⩾6.0. In addition, weight loss and a vacation were risk factors for overanticoagulation. Dietary factors were not associated with overanticoaguation. If risk factors can not be avoided, increased monitoring of INR values could prevent overanticoagulation and potential bleeding complications.
影响因子：
5.3
作者：
FOLSOM, AR;WU, KK;SZKLO, M
通讯作者：
SZKLO, M