Subject-specific multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease.
Subject-specific multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease.
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DOI：
10.1098/rsfs.2017.0019
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发表时间：
2018-02-06
期刊：
影响因子：
4.4
通讯作者：
Ventikos Y
中科院分区：
文献类型：
--
作者：
Guo L;Vardakis JC;Lassila T;Mitolo M;Ravikumar N;Chou D;Lange M;Sarrami-Foroushani A;Tully BJ;Taylor ZA;Varma S;Venneri A;Frangi AF;Ventikos Y
越来越多的证据表明，阿尔茨海默病是一种血管疾病，由脑灌注受损引起，可能受到生活方式强烈影响的心血管危险因素的促进。为了进一步了解这种假说的确切性质，人们对生活方式因素的影响进行了生物力学的研究。使用了灌注实质组织的扩展孔隙弹性模型，并结合了涉及受试者特定网格、渗透性张量图和脑血流变异性的单独工作流程。本文建模中使用的主题特定数据集被收集为前瞻性数据收集的一部分。在两种活动状态（高和低）下，模拟两例男性非吸烟者（对照组和轻度认知障碍（MCI）病例）。结果显示，MCI患者脑脊液/间质液（ISF）清除率略微降低，实质组织位移升高，脑脊液/ISF积聚和引流增加。两例间血流灌注峰值保持在8 mm s−1。
There is emerging evidence suggesting that Alzheimer's disease is a vascular disorder, caused by impaired cerebral perfusion, which may be promoted by cardiovascular risk factors that are strongly influenced by lifestyle. In order to develop an understanding of the exact nature of such a hypothesis, a biomechanical understanding of the influence of lifestyle factors is pursued. An extended poroelastic model of perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and cerebral blood flow variability is used. The subject-specific datasets used in the modelling of this paper were collected as part of prospective data collection. Two cases were simulated involving male, non-smokers (control and mild cognitive impairment (MCI) case) during two states of activity (high and low). Results showed a marginally reduced clearance of cerebrospinal fluid (CSF)/interstitial fluid (ISF), elevated parenchymal tissue displacement and CSF/ISF accumulation and drainage in the MCI case. The peak perfusion remained at 8 mm s−1 between the two cases.
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影响因子：
4
作者：
Garcia de Eulate, Reyes;Goni, Irene;Fernandez-Seara, Maria A.
通讯作者：
Fernandez-Seara, Maria A.
DOI：
10.1001/jama.2017.3090
发表时间：
2017-04-11
期刊：
JAMA
影响因子：
--
作者：
Gottesman RF;Schneider AL;Zhou Y;Coresh J;Green E;Gupta N;Knopman DS;Mintz A;Rahmim A;Sharrett AR;Wagenknecht LE;Wong DF;Mosley TH
通讯作者：
Mosley TH
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
11
作者：
Czosnyka, M;Pickard, JD
通讯作者：
Pickard, JD
DOI：
10.1155/2012/367516
发表时间：
2012
期刊：
Cardiovascular psychiatry and neurology
影响因子：
--
作者：
de la Torre JC
通讯作者：
de la Torre JC