Optimal method for metabolic tumour volume assessment of cervical cancers with inter-observer agreement on [18F]-fluoro-deoxy-glucose positron emission tomography with computed tomography.
Optimal method for metabolic tumour volume assessment of cervical cancers with inter-observer agreement on [18F]-fluoro-deoxy-glucose positron emission tomography with computed tomography.
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DOI：
10.1007/s00259-020-05136-8
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发表时间：
2021-06
影响因子：
9.1
通讯作者：
Barwick TD
中科院分区：
文献类型：
--
作者：
Arshad MA;Gitau S;Tam H;Park WE;Patel NH;Rockall A;Aboagye EO;Bharwani N;Barwick TD
从[18F]-FDG PET/CT中获得的宫颈癌代谢肿瘤体积（MTV）在诊断和治疗计划中具有重要作用。在[18F]-FDG PET/CT上没有标准的方法来概述MTV。本研究的目的是评估最佳方法，以概述原发性宫颈肿瘤的[18 F]-FDG PET/CT使用MRI衍生的肿瘤体积作为参考标准。纳入了81例接受治疗前分期MRI和[18 F]-FDG PET/CT成像的连续宫颈癌患者。采用不同的PET分割方法比较MRI体积。方法1测量了在不同SUV最大阈值下的MTV，范围从20%到60%（MTV 20-MTV 60），需要时进行膀胱掩蔽和手动调节。方法2在应用不同的SUVmax阈值之前在肿瘤周围创建等值线。方法3使用自动梯度法。在需要时进行手动调整后，记录MTV的观察者间一致性。对于方法1，两名阅片人的MTV 25和MTV 30最接近MRI体积（阅片人1和2的MTV 25与MRI体积的平均百分比变化分别为2.9%和13.4%，MTV 30与MRI体积的平均百分比变化分别为-13.1%和-2.0%）。MTV 25时70%的病变需要手动调整，而MTV 30时为45%。观察者之间在MTV 30至MTV 60之间的一致性极佳（ICC范围为0.898-0.976，95%置信区间（CI）较窄），在较低阈值下的一致性中等（MTV 20和MTV 25的ICC估计值分别为0.534和0.617，95% CI较宽）。在86%的病例中进行了膀胱掩蔽。对于方法2，在MTV 25和MTV 30处证明了良好的相关性（对于读片者1和2，MTV 25与MRI体积的平均%变化分别为−3.9%和− 8.6%，MTV 30与MRI体积的平均%变化分别为− 16.9%和19%）。该方法还在所有阈值上显示出优异的ICC，无需手动调整。方法3显示出极好的ICC为0.96（95% CI 0.94-0.97），但与读片者1和2的MRI体积的平均百分比差异分别为-19.1%和-18.2%。21%的阅读器需要手动调整。考虑到阅片员之间的良好一致性和较少的手动调整要求，MTV 30提供了与MRI容积的最佳相关性。在线版本包含补充材料，可通过10.1007/s 00259 -020-05136-8获得。
Cervical cancer metabolic tumour volume (MTV) derived from [18F]-FDG PET/CT has a role in prognostication and therapy planning. There is no standard method of outlining MTV on [18F]-FDG PET/CT. The aim of this study was to assess the optimal method to outline primary cervical tumours on [18F]-FDG PET/CT using MRI-derived tumour volumes as the reference standard. 81 consecutive cervical cancer patients with pre-treatment staging MRI and [18F]-FDG PET/CT imaging were included. MRI volumes were compared with different PET segmentation methods. Method 1 measured MTVs at different SUVmax thresholds ranging from 20 to 60% (MTV20-MTV60) with bladder masking and manual adjustment when required. Method 2 created an isocontour around the tumour prior to different SUVmax thresholds being applied. Method 3 used an automated gradient method. Inter-observer agreement of MTV, following manual adjustment when required, was recorded. For method 1, the MTV25 and MTV30 were closest to the MRI volumes for both readers (mean percentage change from MRI volume of 2.9% and 13.4% for MTV25 and − 13.1% and − 2.0% for MTV30 for readers 1 and 2). 70% of lesions required manual adjustment at MTV25 compared with 45% at MTV30. There was excellent inter-observer agreement between MTV30 to MTV60 (ICC ranged from 0.898–0.976 with narrow 95% confidence intervals (CIs)) and moderate agreement at lower thresholds (ICC estimates of 0.534 and 0.617, respectively for the MTV20 and MTV25 with wide 95% CIs). Bladder masking was performed in 86% of cases overall. For method 2, excellent correlation was demonstrated at MTV25 and MTV30 (mean % change from MRI volume of −3.9% and − 8.6% for MTV25 and − 16.9% and 19% for MTV30 for readers 1 and 2, respectively). This method also demonstrated excellent ICC across all thresholds with no manual adjustment. Method 3 demonstrated excellent ICC of 0.96 (95% CI 0.94–0.97) but had a mean percentage difference from the MRI volume of − 19.1 and − 18.2% for readers 1 and 2, respectively. 21% required manual adjustment for both readers. MTV30 provides the optimal correlation with MRI volume taking into consideration the excellent inter-reader agreement and less requirement for manual adjustment. The online version contains supplementary material available at 10.1007/s00259-020-05136-8.
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影响因子：
2.6
作者：
Akkas, Burcu Esen;Demirel, Busra Bedriye;Vural, Gulin Ucmak
通讯作者：
Vural, Gulin Ucmak
影响因子：
2.3
作者：
Kim, Hun Jung;Kim, Woochul
通讯作者：
Kim, Woochul
DOI：
10.1016/j.ijrobp.2012.02.056
发表时间：
2013-01-01
影响因子：
7
作者：
Kidd, Elizabeth A.;Thomas, Maria;Grigsby, Perry W.
通讯作者：
Grigsby, Perry W.
DOI：
10.1016/j.radonc.2011.12.024
发表时间：
2012-04
期刊：
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
影响因子：
--
作者：
Dimopoulos JC;Petrow P;Tanderup K;Petric P;Berger D;Kirisits C;Pedersen EM;van Limbergen E;Haie-Meder C;Pötter R
通讯作者：
Pötter R
DOI：
10.2967/jnumed.115.167684
发表时间：
2016-06
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Burger IA;Casanova R;Steiger S;Husmann L;Stolzmann P;Huellner MW;Curioni A;Hillinger S;Schmidtlein CR;Soltermann A
通讯作者：
Soltermann A