Role of myeloid-derived suppressor cells in viral respiratory infections; Hints for discovering therapeutic targets for COVID-19.
Role of myeloid-derived suppressor cells in viral respiratory infections; Hints for discovering therapeutic targets for COVID-19.
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DOI：
10.1016/j.biopha.2021.112346
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Ghaemi A
中科院分区：
文献类型：
--
作者：
Koushki K;Salemi M;Miri SM;Arjeini Y;Keshavarz M;Ghaemi A
髓源性抑制细胞（MDSC），称为不成熟髓细胞的异质群体，在几种病理条件下，如炎症或病毒性呼吸道感染，扩增增强。看来MDSC在感染中的行为方式取决于入侵病原体的类型和毒力机制、疾病阶段和感染相关的病理。越来越多的证据表明，与疾病的严重程度相关，MDSC在COVID-19患者中积累，特别是在疾病的严重阶段或ICU患者中，有助于SARS-CoV 2感染的发病机制。基于所涉及的亚群，MDSC通过采用各种机制，例如诱导抗炎细胞因子的分泌、诱导型一氧化氮合酶（iNOS）介导的IFN-γ产生的阻碍或迫使精氨酸短缺，通过抑制T细胞增殖和应答来延迟病毒的清除。虽然MDSC的免疫抑制特征可能有助于保持组织稳态并防止感染早期的过度炎症，但事实证明，阻碍有效的免疫反应对严重形式的COVID-19产生显着的致病作用，这表明MDSC的靶向作用是一种潜在的干预措施，可以重新激活T细胞免疫，从而防止感染发展为疾病的严重阶段。本文综述了MDSC不同亚群在病毒性呼吸道感染中的作用，并介绍了MDSC在开发新的诊断和治疗方法，特别是针对COVID-19疾病的潜力。
The expansion of myeloid-derived suppressor cells (MDSCs), known as heterogeneous population of immature myeloid cells, is enhanced during several pathological conditions such as inflammatory or viral respiratory infections. It seems that the way MDSCs behave in infection depends on the type and the virulence mechanisms of the invader pathogen, the disease stage, and the infection-related pathology. Increasing evidence showing that in correlation with the severity of the disease, MDSCs are accumulated in COVID-19 patients, in particular in those at severe stages of the disease or ICU patients, contributing to pathogenesis of SARS-CoV2 infection. Based on the involved subsets, MDSCs delay the clearance of the virus through inhibiting T-cell proliferation and responses by employing various mechanisms such as inducing the secretion of anti-inflammatory cytokines, inducible nitric oxide synthase (iNOS)-mediated hampering of IFN-γ production, or forcing arginine shortage. While the immunosuppressive characteristic of MDSCs may help to preserve the tissue homeostasis and prevent hyperinflammation at early stages of the infection, hampering of efficient immune responses proved to exert significant pathogenic effects on severe forms of COVID-19, suggesting the targeting of MDSCs as a potential intervention to reactivate T-cell immunity and thereby prevent the infection from developing into severe stages of the disease. This review tried to compile evidence on the roles of different subsets of MDSCs during viral respiratory infections, which is far from being totally understood, and introduce the promising potential of MDSCs for developing novel diagnostic and therapeutic approaches, especially against COVID-19 disease.
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影响因子：
10.1
作者：
Gabrilovich DI
通讯作者：
Gabrilovich DI
DOI：
10.1186/cc14003
发表时间：
2014-08-01
期刊：
Critical care (London, England)
影响因子：
--
作者：
Darcy CJ;Minigo G;Piera KA;Davis JS;McNeil YR;Chen Y;Volkheimer AD;Weinberg JB;Anstey NM;Woodberry T
通讯作者：
Woodberry T
影响因子：
11.8
作者：
Bordoni, Veronica;Sacchi, Alessandra;Agrati, Chiara
通讯作者：
Agrati, Chiara
DOI：
10.1164/rccm.201302-0249oc
发表时间：
2013-09-15
影响因子：
24.7
作者：
du Plessis, Nelita;Loebenberg, Laurianne;Walzl, Gerhard
通讯作者：
Walzl, Gerhard
影响因子：
12.4
作者：
Agrati, Chiara;Sacchi, Alessandra;Ippolito, Giuseppe
通讯作者：
Ippolito, Giuseppe