Individual differences in fear learning: Specificity to trait-anxiety beyond other measures of negative affect, and mediation via amygdala activation
Individual differences in fear learning: Specificity to trait-anxiety beyond other measures of negative affect, and mediation via amygdala activation
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恐惧学习的个体差异：特质焦虑的特异性超出其他负面影响的衡量标准，以及通过杏仁核激活进行调节
DOI：
10.1101/233528
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Tina B.
中科院分区：
文献类型：
--
作者：
Sjouwerman;Rachel;Scharfenort;Robert;Lonsdorf;Tina B.
识别个体在区分威胁和安全信号的能力方面的差异，对于阐明病理性焦虑和恢复力的病因机制具有巨大的潜力，并可能最终促进有针对性的预防和临床干预计划的发展。在不同的研究中，可以被归入负面情绪的总术语下的结构，如特质焦虑（STAI-T），神经质（N）和不确定性的不容忍（IU），被认为有助于异常的恐惧学习。然而，这些结构之间的共线性和个体的贡献与恐惧学习，以及神经生物学机制仍然不清楚。在这里，我们在两个独立的样本（Nbehavioral研究1=288;NfMRI研究2= 116）中，在差异恐惧条件反射范式中，应用多变量和多维方法（结构方程模型）跨多个单元的分析（评级，皮肤电导，恐惧增强惊吓，fMRI）。特质焦虑被确定为独特的方面的负面影响预测差异的歧视信号的威胁和安全的皮肤电导反应超出其他措施的负面影响（N，IU）。这是重复的第二个独立的样本，并通过显示特质焦虑和皮肤电导反应之间的关联是由杏仁核激活介导的。这些研究结果阐明了一个有趣的机制（歧视赤字），个人的倾向，体验焦虑相关的情绪可能会赋予一种倾向的发展病理性焦虑，因此建议一个可能的机制目标（即歧视培训）的临床干预和预防。
Identifying individual differences in the ability to discriminate signals of threat and safety holds great potential to elucidate etiological mechanisms of pathological anxiety and resilience and may ultimately foster the development of targeted prevention and clinical intervention programs. Constructs that can be subsumed under the umbrella term of negative affect such as trait-anxiety (STAI-T), neuroticism (N), and intolerance of uncertainty (IU) have been suggested to contribute to aberrant fear learning in different studies. However, collinearity between and individual contributions of these constructs in relation to fear learning, as well as the neurobiological mechanisms remain unclear. Here, we apply a multivariate and dimensional approach (structural equation modeling) across multiple units of analyses (ratings, skin conductance, fear potentiated startle, fMRI) in a differential fear conditioning paradigm in two independent samples (Nbehavioral study 1=288;NfMRI study 2= 116). Trait-anxiety was identified as the unique facet of negative affect predicting differences in discriminating signals of threat and safety in skin conductance responses beyond other measures of negative affect (N, IU). This was replicated in a second independent sample and extended by showing that the association between trait-anxiety and skin conductance responding is mediated by differential amygdala activation. These findings elucidate an intriguing mechanism (discrimination deficits) by which the individual’s disposition to experience anxiety-relevant emotions may confer a predisposition to the development of pathological anxiety and hence suggest a possible mechanistic target (i.e. discrimination training) for clinical intervention and prevention.
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影响因子：
16.4
作者：
Lahey, Benjamin B.
通讯作者：
Lahey, Benjamin B.
通用意向模型的定义和德国版本的不安全性的解释
DOI：
--
发表时间：
2008
期刊：
影响因子：
--
作者：
A. Gerlach;Tanja Andor;Julia Patzelt
通讯作者：
Julia Patzelt
DOI：
--
发表时间：
1970
期刊：
--
影响因子：
--
作者：
C. Spielberger;R. Gorsuch;R. Lushene
通讯作者：
C. Spielberger;R. Gorsuch;R. Lushene
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影响因子：
4.1
作者：
Sara Scheveneels;Y. Boddez;B. Vervliet;D. Hermans
通讯作者：
D. Hermans
影响因子：
3.7
作者：
McEvoy, Peter M.;Mahoney, Alison E. J.
通讯作者：
Mahoney, Alison E. J.