Targeting Phospholipid Metabolism in Cancer.
Targeting Phospholipid Metabolism in Cancer.
复制标题
针对癌症中的磷脂代谢。
DOI：
10.3389/fonc.2016.00266
复制
发表时间：
2016
影响因子：
4.7
通讯作者：
Glunde K
中科院分区：
文献类型：
--
作者：
Cheng M;Bhujwalla ZM;Glunde K
迄今为止测试的所有癌症都显示出异常的胆碱和乙醇胺磷脂代谢，这已经在细胞、癌症动物模型以及癌症患者的肿瘤中用许多磁共振波谱（MRS）方法检测到。自从发现这种癌症的代谢标志以来，已经进行了许多研究来阐明胆碱代谢失调的分子起源，以确定癌症治疗的靶点，并开发检测胆碱和乙醇胺化合物的MRS方法，用于临床诊断和治疗监测。胆碱中的几种酶，最近也乙醇胺，磷脂代谢已被确定，他们的评估表明，他们参与致癌和肿瘤进展。几种已经建立的酶以及磷脂代谢中的许多新兴酶可以单独或与其他化疗方法组合用作抗癌疗法的治疗靶点。本文综述了肿瘤磷脂代谢的新靶点，包括胆碱激酶α、磷脂酰胆碱特异性磷脂酶D1、磷脂酰胆碱特异性磷脂酶C、鞘磷脂酶、胆碱转运蛋白、甘油磷酸二酯酶、磷脂酰乙醇胺N-甲基转移酶和乙醇胺激酶。这些酶在致癌转化，肿瘤进展和关键的癌细胞特性，如快速增殖，迁移和入侵方面的作用进行了讨论。基于当前文献，评价了它们作为治疗靶点的潜力。
All cancers tested so far display abnormal choline and ethanolamine phospholipid metabolism, which has been detected with numerous magnetic resonance spectroscopy (MRS) approaches in cells, animal models of cancer, as well as the tumors of cancer patients. Since the discovery of this metabolic hallmark of cancer, many studies have been performed to elucidate the molecular origins of deregulated choline metabolism, to identify targets for cancer treatment, and to develop MRS approaches that detect choline and ethanolamine compounds for clinical use in diagnosis and treatment monitoring. Several enzymes in choline, and recently also ethanolamine, phospholipid metabolism have been identified, and their evaluation has shown that they are involved in carcinogenesis and tumor progression. Several already established enzymes as well as a number of emerging enzymes in phospholipid metabolism can be used as treatment targets for anticancer therapy, either alone or in combination with other chemotherapeutic approaches. This review summarizes the current knowledge of established and relatively novel targets in phospholipid metabolism of cancer, covering choline kinase α, phosphatidylcholine-specific phospholipase D1, phosphatidylcholine-specific phospholipase C, sphingomyelinases, choline transporters, glycerophosphodiesterases, phosphatidylethanolamine N-methyltransferase, and ethanolamine kinase. These enzymes are discussed in terms of their roles in oncogenic transformation, tumor progression, and crucial cancer cell properties such as fast proliferation, migration, and invasion. Their potential as treatment targets are evaluated based on the current literature.
登录
查看更多内容
影响因子：
5.7
作者：
Beloueche-Babari, M;Jackson, LE;Ronen, SM
通讯作者：
Ronen, SM
影响因子：
37.3
作者：
Chua BT;Gallego-Ortega D;Ramirez de Molina A;Ullrich A;Lacal JC;Downward J
通讯作者：
Downward J
影响因子：
4.1
作者：
Aoyama, C;Ohtani, A;Ishidate, K
通讯作者：
Ishidate, K
影响因子：
11.2
作者：
Al-Saffar, NMS;Troy, H;Chung, YL
通讯作者：
Chung, YL
影响因子：
19.7
作者：
Bartella, L;Morris, EA;Huang, W
通讯作者：
Huang, W