Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.
Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.
复制标题
皮质厚度介导 DRD2 C957T 多态性与成人寿命执行功能之间的关系。
DOI：
10.1007/s00429-020-02169-5
复制
发表时间：
2021-01
影响因子：
3.1
通讯作者：
Kennedy KM
中科院分区：
文献类型：
--
作者：
Miranda GG;Rodrigue KM;Kennedy KM
Dopamine (DA) signaling is critical for optimal cognitive performance. Aging is accompanied by a change in the strength of this signaling, with a loss of striatal and extrastriatal D2 binding potential. The reduction in dopamine modulation with age negatively influences various aspects of cognition. DRD2 C957T (rs6277) impacts DA D2 receptor density and availability, with C homozygotes linked to lower striatal DA availability and reduced executive functioning (EF), but also high extrastriatal binding potential. Here, we investigated in 176 participants aged 20–94 years whether: (1) DRD2 C carriers differ from T carriers in cortical thickness or subcortical volume in areas of high concentrations of D2 receptors that receive projections from mesocortical or nigrostriatal dopaminergic pathways; (2) whether the DRD2*COMT relationship has any synergistic effects on cortical thickness; (3) whether the effect of DRD2 on brain structure depends upon age; and (4) whether DRD2-related regional thinning affects executive function performance. We show that DRD2 impacts cortical thickness in the superior parietal lobule, precuneus, and anterior cingulate (marginal after FDR correction), while statistically controlling sex, age, and COMT genotype. Specifically, C homozygotes demonstrated thinner cortices than both heterozygotes and/or T homozygotes in an age-invariant manner. Additionally, DRD2 predicted executive function performance via cortical thickness. The results highlight that genetic influences on dopamine availability impact cognitive performance via the contribution of brain structure in cortical regions influenced by DRD2.
登录
查看更多内容
DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
3.3
作者：
Cerasa, A.;Cherubini, A.;Spalletta, G.
通讯作者：
Spalletta, G.
影响因子：
3.7
作者：
Garcia-Garcia M;Via M;Zarnowiec K;SanMiguel I;Escera C;Clemente IC
通讯作者：
Clemente IC
影响因子：
2.6
作者：
Heaton, Michael P.;Keele, John W.;Harhay, Gregory P.;Richt, Juergen A.;Koohmaraie, Mohammad;Wheeler, Tommy L.;Shackelford, Steven D.;Casas, Eduardo;King, D. Andy;Sonstegard, Tad S.;Van Tassell, Curtis P.;Neibergs, Holly L.;Chase, Chad C., Jr.;Kalbfleisch, Theodore S.;Smith, Timothy P. L.;Clawson, Michael L.;Laegreid, William W.
通讯作者：
Laegreid, William W.