Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases.
Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases.
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DOI：
10.3390/ijms19082208
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发表时间：
2018-07-28
影响因子：
5.6
通讯作者：
Pan MH
中科院分区：
文献类型：
--
作者：
Koh YC;Yang G;Lai CS;Weerawatanakorn M;Pan MH
巨噬细胞可以极化成两种不同的状态（M1和M2），在发病或组织损伤过程中发挥着不同的作用。M1极化巨噬细胞产生促炎细胞因子和引起炎症的介质，而M2极化巨噬细胞具有抗炎作用。巨噬细胞分泌适当的细胞因子和趋化因子可导致微环境的改变，以桥接先天和适应性免疫反应。越来越多的证据表明，巨噬细胞极化是疾病进展的关键，巨噬细胞极化的调节可能为炎症相关疾病的治疗提供新的途径，包括癌症、肥胖和代谢性疾病、器官纤维化、脑损伤和神经元损伤以及结直肠疾病。极化巨噬细胞通过分泌细胞因子和趋化因子影响微环境，而驻留细胞或组织产生的细胞因子或介质也可能影响巨噬细胞的行为。巨噬细胞与其他细胞的相互作用可以影响疾病的进展，因此，在采取治疗或预防措施之前，了解巨噬细胞的活化以及极化巨噬细胞与疾病进展之间的相互作用是必要的。巨噬细胞的操作可能是疾病改善的切入点，但其机制和潜力必须了解。本文将对巨噬细胞在不同疾病中的作用、可能的机制以及对巨噬细胞极化有效的药物或植物化学物质的干预等方面的研究进展进行综述。
Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.
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miR-181a 通过靶向 KLF6 和 C/EBPα 诱导巨噬细胞极化为 M2 表型并促进 M2 巨噬细胞介导的肿瘤细胞转移。
DOI：
10.1038/mtna.2016.71
发表时间：
2016-09-27
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
通讯作者：
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影响因子：
6.6
作者：
Gu Q;Yang H;Shi Q
通讯作者：
Shi Q
影响因子：
3.7
作者：
Barrett, James P.;Minogue, Aedin M.;Lynch, Marina A.
通讯作者：
Lynch, Marina A.
影响因子：
4.7
作者：
Hood JL
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Hood JL
影响因子：
11.1
作者：
Feng X;Weng D;Zhou F;Owen YD;Qin H;Zhao J;WenYu;Huang Y;Chen J;Fu H;Yang N;Chen D;Li J;Tan R;Shen P
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