Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice.
Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice.
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DOI：
10.3389/fnmol.2020.534238
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发表时间：
2020
影响因子：
4.8
通讯作者：
Steele AD
中科院分区：
文献类型：
--
作者：
Gallardo CM;Martin CS;Steele AD
许多研究表明生物胺参与调节昼夜节律。特别是，多巴胺和血清素影响昼夜节律对每日食物供应的影响。为了研究昼夜节律对摄食的影响，食物的可用性通常被限制在每日光周期内的短时间内。这导致餐前活动显著增加，称为“食物预期活动”（FAA），通常在计划喂养的约1周内发展。几项研究表明血清素是FAA的负调节剂：（1）用5-羟色胺5-HT 2和3受体拮抗剂治疗的老年大鼠显示FAA增强，（2）缺乏2C血清素受体的小鼠显示FAA增强，（3）血清素水平显著升高抑制小鼠FAA，而血清素水平降低增强小鼠FAA。我们试图使用中枢5-羟色胺产生或再摄取受损的遗传模型来证实和扩展这些发现，但惊讶地发现，5-羟色胺转运蛋白（Slc 6a 4）和色氨酸羟化酶-2基因敲除小鼠对定时、热量限制的喂养表现出正常的行为反应。我们的数据表明，FAA在很大程度上是独立的中央血清素和/或血清素再摄取，血清素可能不是一个强大的负调节FAA。
A number of studies implicate biogenic amines in regulating circadian rhythms. In particular, dopamine and serotonin influence the entrainment of circadian rhythms to daily food availability. To study circadian entrainment to feeding, food availability is typically restricted to a short period within the light cycle daily. This results in a notable increase in pre-meal activity, termed “food anticipatory activity” (FAA), which typically develops within about 1 week of scheduled feeding. Several studies have implicated serotonin as a negative regulator of FAA: (1) aged rats treated with serotonin 5-HT2 and 3 receptor antagonists showed enhanced FAA, (2) mice lacking for the 2C serotonin receptor demonstrate enhanced FAA, and (3) pharmacologically increased serotonin levels suppressed FAA while decreased serotonin levels enhanced FAA in mice. We sought to confirm and extend these findings using genetic models with impairments in central serotonin production or re-uptake, but were surprised to find that both serotonin transporter (Slc6a4) and tryptophan hydroxylase-2 knockout mice demonstrated a normal behavioral response to timed, calorie restricted feeding. Our data suggest that FAA is largely independent of central serotonin and/or serotonin reuptake and that serotonin may not be a robust negative regulator of FAA.
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DOI：
10.1523/jneurosci.3905-08.2009
发表时间：
2009-06-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Abdallah L;Bonasera SJ;Hopf FW;O'Dell L;Giorgetti M;Jongsma M;Carra S;Pierucci M;Di Giovanni G;Esposito E;Parsons LH;Bonci A;Tecott LH
通讯作者：
Tecott LH
影响因子：
5.3
作者：
Morelli, Emanuela;Moore, Holly;Ansorge, Mark S.
通讯作者：
Ansorge, Mark S.
影响因子：
5
作者：
Narboux-Neme, Nicolas;Angenard, Gaelle;Gaspar, Patricia
通讯作者：
Gaspar, Patricia
影响因子：
1.9
作者：
Michalik, Mateusz;Steele, Andrew D.;Mistlberger, Ralph E.
通讯作者：
Mistlberger, Ralph E.
DOI：
10.1073/pnas.0810793106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Alenina, Natalia;Kikic, Dana;Bader, Michael
通讯作者：
Bader, Michael