Update on Immune Mechanisms in Hypertension.

Update on Immune Mechanisms in Hypertension.
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DOI:
10.1093/ajh/hpac077
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发表时间:
2022-10-03
影响因子:
3.2
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
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免疫细胞在高血压的发生和维持中的作用是不可否认的。几项研究已经建立了高血压,炎症和来自先天性和适应性免疫系统的免疫细胞之间的联系。在这里,我们提供了对2017年美国高血压杂志综述的更新,该综述概述了高血压中涉及的细胞免疫反应。此外,我们还讨论了免疫细胞的激活及其在不同体内模型中对高血压发病机制的贡献。我们还强调了需要关注的高血压领域的现有差距。本综述的主要目标是为转化研究提供知识基础,以开发可改善人类心血管健康的治疗策略。
The contribution of immune cells in the initiation and maintenance of hypertension is undeniable. Several studies have established the association between hypertension, inflammation, and immune cells from the innate and adaptive immune systems. Here, we provide an update to our 2017 American Journal of Hypertension review on the overview of the cellular immune responses involved in hypertension. Further, we discuss the activation of immune cells and their contribution to the pathogenesis of hypertension in different in vivo models. We also highlight existing gaps in the field of hypertension that need attention. The main goal of this review is to provide a knowledge base for translational research to develop therapeutic strategies that can improve cardiovascular health in humans.
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