Pathological Features of Free Graft and Pedicled Flap in the Nasal Cavity: An Animal Study
Pathological Features of Free Graft and Pedicled Flap in the Nasal Cavity: An Animal Study
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鼻腔游离移植物和带蒂皮瓣的病理特征：动物研究
DOI：
10.1002/lary.28630
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发表时间：
2020
期刊：
影响因子：
2.6
通讯作者：
Yasuhiro Tanaka
中科院分区：
文献类型：
--
作者：
Kosuke Tochigi;Kazuhiro Omura;Keisuke Miyashita;Satoshi Aoki;Nobuyoshi Otori;Yasuhiro Tanaka
目的/假设最近发展的利用粘骨膜材料的粘膜缺损重建技术使鼻内窥镜手术后的生理功能迅速恢复。临床试验已经描述了游离移植和带蒂皮瓣的优点、缺点和不同的结果，它们分别牺牲或保留血流。然而，组织学变化，影响重建后的术后结果，仍然不清楚。我们创建了一个动物模型，粘膜缺损的重建，使用游离移植物和带蒂皮瓣，并评估他们的histologic.Study DesignAnimal study.MethodsWe创建了粘膜缺损，在左鼻中隔的20只兔子，并进行重建与游离移植物和带蒂皮瓣。7天和28天后，使用苏木素和伊红染色切片评估重建部位睫状细胞和杯状细胞的分布，以计算睫状细胞指数和杯状细胞指数。炎症的严重程度进行了评估，使用Carpendum炎性细胞Score.ResultsCrusting和粘膜形态的变化在重建网站只发生在游离移植组。此外，带蒂皮瓣组有显着更大的保护睫状体和杯状细胞和更少的炎性细胞浸润到隔软骨（P< .05）比游离移植group.ConclusionsAfter重建程序粘膜缺损，组织病理学差异观察之间的自由移植和带蒂皮瓣。带蒂皮瓣重建具有保存健康粘膜上皮和抑制重建部位炎症的优点。这表明带蒂皮瓣重建可能优于游离移植物。证据等级NALryngoscope，131：E428-E433，2021
Objectives/HypothesisRecent developments in reconstructive techniques for mucosal defects using mucoperiosteal materials have enabled rapid recovery of physiological function after endoscopic sinus surgery. Clinical trials have described the advantages, disadvantages, and different outcomes of free graft and pedicled flap, which, respectively, sacrifice or preserve blood flow. However, histological changes, that affect the postoperative outcomes after reconstruction, remain unclear. We created an animal model for the reconstruction of mucosal defects using free grafts and pedicled flaps, and evaluated them histologically.Study DesignAnimal study.MethodsWe created mucosal defects in the left nasal septum of 20 rabbits and performed reconstruction with free grafts and pedicled flaps. The distribution of ciliary and goblet cells at the reconstruction site was evaluated after 7 and 28 days using hematoxylin and eosin–stained sections to calculate the Ciliary Cell Index and Goblet Cell Index. The severity of inflammation was assessed using the Cartilage Inflammatory Cell Score.ResultsCrusting and changes in the mucosal morphology at the reconstruction site occurred only in the free graft group. In addition, the pedicled flap group had significantly greater preservation of ciliary and goblet cells and less inflammatory cell infiltration into the septal cartilage (P< .05) than the free graft group.ConclusionsAfter reconstruction procedures for mucosal defects, histopathological differences were observed between the free graft and pedicled flap. Reconstruction with pedicled flaps had advantages including preservation of healthy mucosal epithelium and suppression of inflammation on the reconstruction site. This indicated that reconstruction with pedicled flaps might have advantages over that with free grafts.Level of EvidenceNALaryngoscope, 131:E428–E433, 2021
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颞筋膜带蒂下鼻甲粘膜瓣内镜修复大型鼻中隔穿孔的效果
DOI：
10.1159/000453269
发表时间：
2016
期刊：
ORL
影响因子：
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作者：
Ming Xu;Yong He;Xia Bai
通讯作者：
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影响因子：
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发表时间：
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期刊：
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Fichter AM;Ritschl LM;Borgmann A;Humbs M;Luppa PB;Wolff KD;Mücke T
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影响因子：
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