Adrenergic nerves govern circadian leukocyte recruitment to tissues.
Adrenergic nerves govern circadian leukocyte recruitment to tissues.
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DOI：
10.1016/j.immuni.2012.05.021
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发表时间：
2012-08-24
期刊：
影响因子：
32.4
通讯作者：
Frenette PS
中科院分区：
文献类型：
--
作者：
Scheiermann C;Kunisaki Y;Lucas D;Chow A;Jang JE;Zhang D;Hashimoto D;Merad M;Frenette PS
导致白细胞迁移的多步骤序列被认为在炎症部位受到局部调节。在这里，我们表明，广泛的系统程序涉及从交感神经系统（SNS）的肾上腺素能神经传递的长距离信号，调节组织中白细胞的节律性募集。白细胞在小鼠骨髓和骨骼肌微血管中的粘附和迁移在夜间出现昼夜高峰。由实验时差改变的迁移振荡由血管周围SNS纤维实现，作用于非造血细胞上表达的β-肾上腺素受体，并导致内皮细胞粘附分子和趋化因子表达的组织特异性差异昼夜节律振荡。我们发现，这些节奏有生理后果的造血细胞募集和总生存率在感染性休克，镰状细胞血管闭塞和骨髓移植模型的改变。这些数据为白细胞粘附级联反应提供了独特的见解，并为移植和炎症性疾病提供了基于时间的治疗潜力。
The multistep sequence leading to leukocyte migration is thought to be locally regulated at the inflammatory site. Here, we show that broad systemic programs involving long-range signals from the sympathetic nervous system (SNS) delivered by adrenergic nerves, regulate rhythmic recruitment of leukocytes in tissues. Constitutive leukocyte adhesion and migration in murine bone marrow (BM) and skeletal muscle microvasculature fluctuated with circadian peak values at night. Migratory oscillations, altered by experimental jetlag, were implemented by perivascular SNS fibers, acting on β-adrenoreceptors expressed on non-hematopoietic cells, and leading to tissue-specific, differential circadian oscillations in the expression of endothelial cell adhesion molecules and chemokines. We showed that these rhythms have physiological consequences by alteration of hematopoietic cell recruitment and overall survival in models of septic shock, sickle cell vaso-occlusion and BM transplantation. These data provide unique insight in the leukocyte adhesion cascade and the potential for time-based therapeutics for transplantation and inflammatory diseases.
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DOI：
10.1073/pnas.1106750109
发表时间：
2012-01-10
影响因子：
11.1
作者：
Gibbs, Julie E.;Blaikley, John;Loudon, Andrew S. I.
通讯作者：
Loudon, Andrew S. I.
影响因子：
37.8
作者：
Anea CB;Zhang M;Stepp DW;Simkins GB;Reed G;Fulton DJ;Rudic RD
通讯作者：
Rudic RD
DOI：
10.4049/jimmunol.1001026
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castanon-Cervantes O;Wu M;Ehlen JC;Paul K;Gamble KL;Johnson RL;Besing RC;Menaker M;Gewirtz AT;Davidson AJ
通讯作者：
Davidson AJ
影响因子：
48
作者：
Chiang, Elaine Y.;Hidalgo, Andres;Frenette, Paul S.
通讯作者：
Frenette, Paul S.
影响因子：
64.5
作者：
Frenette, PS;Mayadas, TN;Wagner, DD
通讯作者：
Wagner, DD