γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.
γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.
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DOI：
10.1016/j.bcmd.2023.102746
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发表时间：
2023-07
影响因子：
2.3
通讯作者：
Farrell, David H.
中科院分区：
文献类型：
--
作者：
Kornblith, Lucy Z.;Sadhanandhan, Bindhya;Arun, Sreepriya;Long, Rebecca;Johnson, Alicia J.;Noll, Jamie;Ramchand, C. N.;Olynyk, John K.;Farrell, David H.
2019冠状病毒病（COVID-19）的特征是与器官衰竭、血栓形成和死亡相关的促炎状态。我们在103名COVID-19住院患者和19名健康对照者中研究了一种新的炎症生物标志物γ′纤维蛋白原（GPF）。我们发现GPF水平与COVID-19的严重程度（通过血氧饱和度（SpO 2）判断）之间存在显著相关性。COVID-19患者的GPF平均水平显著高于对照组（69.8（95% CI 64.8-74.8）mg/dL，与36.9 mg/dL相比（95%CI 31.4-42.4）mg/dL，p < 0.0001），而C-反应蛋白（CRP），乳酸脱氢酶（LDH），和总纤维蛋白原水平在组间没有显著差异。严重COVID-19患者的平均GPF水平显著最高（SpO 2 ≤ 93%，GPF 75.2（95% CI 68.7-81.8）mg/dL），与轻度/中度COVID-19相比（SpO 2> 93%，GPF 62.5（95% CI 55.0-70.0）mg/dL，p = 0.01，AUC 0.68，95% CI 0.57-0.78;约登指数临界点62.9 mg/dL，灵敏度0.64，特异性0.63）。相比之下，CRP、白细胞介素-6、铁蛋白、LDH、D-二聚体和总纤维蛋白原与COVID-19疾病严重程度的相关性较弱（所有ROC曲线的AUC均较低）。因此，GPF可能是COVID-19呼吸道疾病严重程度的有用炎症标志物。
Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ′ fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO2). The mean level of GPF in the patients with COVID-19 was significantly higher than in controls (69.8 (95 % CI 64.8–74.8) mg/dL compared with 36.9 (95 % CI 31.4–42.4) mg/dL, p < 0.0001), whereas C-reactive protein (CRP), lactate dehydrogenase (LDH), and total fibrinogen levels were not significantly different between groups. Mean GPF levels were significantly highest in patients with severe COVID-19 (SpO2 ≤ 93 %, GPF 75.2 (95 % CI 68.7–81.8) mg/dL), compared to mild/moderate COVID-19 (SpO2 > 93 %, GPF 62.5 (95 % CI 55.0–70.0) mg/dL, p = 0.01, AUC of 0.68, 95 % CI 0.57–0.78; Youden's index cutpoint 62.9 mg/dL, sensitivity 0.64, specificity 0.63). In contrast, CRP, interleukin-6, ferritin, LDH, D-dimers, and total fibrinogen had weaker associations with COVID-19 disease severity (all ROC curves with lower AUCs). Thus, GPF may be a useful inflammatory marker of COVID-19 respiratory disease severity.
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影响因子：
6.7
作者：
Alexander, Kristine S.;Madden, Theresa E.;Farrell, David H.
通讯作者：
Farrell, David H.
DOI：
10.1161/atvbaha.115.306284
发表时间：
2015-12-01
影响因子：
8.7
作者：
Appiah, Duke;Schreiner, Pamela J.;Folsom, Aaron R.
通讯作者：
Folsom, Aaron R.
影响因子：
7.5
作者：
Rein-Smith, Chantelle M.;Anderson, Nathan W.;Farrell, David H.
通讯作者：
Farrell, David H.
DOI：
10.1056/nejmoa2103417
发表时间：
2021-08-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
REMAP-CAP Investigators;ACTIV-4a Investigators;ATTACC Investigators;Goligher EC;Bradbury CA;McVerry BJ;Lawler PR;Berger JS;Gong MN;Carrier M;Reynolds HR;Kumar A;Turgeon AF;Kornblith LZ;Kahn SR;Marshall JC;Kim KS;Houston BL;Derde LPG;Cushman M;Tritschler T;Angus DC;Godoy LC;McQuilten Z;Kirwan BA;Farkouh ME;Brooks MM;Lewis RJ;Berry LR;Lorenzi E;Gordon AC;Ahuja T;Al-Beidh F;Annane D;Arabi YM;Aryal D;Baumann Kreuziger L;Beane A;Bhimani Z;Bihari S;Billett HH;Bond L;Bonten M;Brunkhorst F;Buxton M;Buzgau A;Castellucci LA;Chekuri S;Chen JT;Cheng AC;Chkhikvadze T;Coiffard B;Contreras A;Costantini TW;de Brouwer S;Detry MA;Duggal A;Džavík V;Effron MB;Eng HF;Escobedo J;Estcourt LJ;Everett BM;Fergusson DA;Fitzgerald M;Fowler RA;Froess JD;Fu Z;Galanaud JP;Galen BT;Gandotra S;Girard TD;Goodman AL;Goossens H;Green C;Greenstein YY;Gross PL;Haniffa R;Hegde SM;Hendrickson CM;Higgins AM;Hindenburg AA;Hope AA;Horowitz JM;Horvat CM;Huang DT;Hudock K;Hunt BJ;Husain M;Hyzy RC;Jacobson JR;Jayakumar D;Keller NM;Khan A;Kim Y;Kindzelski A;King AJ;Knudson MM;Kornblith AE;Kutcher ME;Laffan MA;Lamontagne F;Le Gal G;Leeper CM;Leifer ES;Lim G;Gallego Lima F;Linstrum K;Litton E;Lopez-Sendon J;Lother SA;Marten N;Saud Marinez A;Martinez M;Mateos Garcia E;Mavromichalis S;McAuley DF;McDonald EG;McGlothlin A;McGuinness SP;Middeldorp S;Montgomery SK;Mouncey PR;Murthy S;Nair GB;Nair R;Nichol AD;Nicolau JC;Nunez-Garcia B;Park JJ;Park PK;Parke RL;Parker JC;Parnia S;Paul JD;Pompilio M;Quigley JG;Rosenson RS;Rost NS;Rowan K;Santos FO;Santos M;Santos MO;Satterwhite L;Saunders CT;Schreiber J;Schutgens REG;Seymour CW;Siegal DM;Silva DG Jr;Singhal AB;Slutsky AS;Solvason D;Stanworth SJ;Turner AM;van Bentum-Puijk W;van de Veerdonk FL;van Diepen S;Vazquez-Grande G;Wahid L;Wareham V;Widmer RJ;Wilson JG;Yuriditsky E;Zhong Y;Berry SM;McArthur CJ;Neal MD;Hochman JS;Webb SA;Zarychanski R
通讯作者：
Zarychanski R
影响因子：
120.7
作者：
Udell, Jacob A.;Zawi, Rami;Cannon, Christopher P.
通讯作者：
Cannon, Christopher P.