Estradiol Levels and Secretory Dynamics in Normal Girls and Boys as Determined by an Ultrasensitive Bioassay: A 10 Year Experience
Estradiol Levels and Secretory Dynamics in Normal Girls and Boys as Determined by an Ultrasensitive Bioassay: A 10 Year Experience
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通过超灵敏生物测定测定正常女孩和男孩的雌二醇水平和分泌动态：10 年经验
DOI：
10.1515/jpem.2006.19.7.901
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发表时间：
2006
影响因子：
1.4
通讯作者：
Karen Oerter Klein
中科院分区：
文献类型：
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作者：
Mona Janfaza;T. I. Sherman;K. Larmore;J. Brown;Karen Oerter Klein
我们利用超灵敏的重组细胞生物测定法测定了800名正常儿童从出生到青春期的血清雌二醇水平。105名儿童在接近青春期时每4个月重复一次样本。我们对55名儿童进行了24小时内每小时雌二醇水平的测量。雌二醇随年龄和青春期阶段的增加而升高，且在各个时期女孩均高于男孩。青春期前女孩雌二醇水平为1.6+/-2.6pg/ml，青春期前男孩雌二醇水平为0.4±1.1pg/ml，女孩和男孩雌二醇水平有日变化，低谷分别出现在08.00-20.00小时和12.00-20.00小时。我们证实，甚至在青春期的生理迹象之前，女孩的雌二醇水平就高于男孩，而且女孩和男孩的雌二醇在整个青春期都会增加。这项对800名儿童的10年经验通过一种超灵敏的生物测定方法显示了雌二醇的范围和变异性。
We utilized an ultrasensitive recombinant cell bioassay to measure serum estradiol in 800 normal children from birth through puberty. 105 children had repeat samples every 4 months as they approached puberty. We measured estradiol levels every hour for 24 hours in 55 children. Estradiol increased with age and pubertal stage in girls and boys, and was higher in girls than boys at each stage. Prepubertal girls have estradiol levels of 1.6 +/- 2.6 pg/ml. Prepubertal boys have estradiol levels of 0.4 + 1.1 pg/ml. Estradiol had a diurnal variation in girls and boys, with the trough occurring 08.00-20.00 h in girls, and 12.00-20.00 h in boys. We confirm that estradiol levels are higher in girls than boys even before physical signs of puberty, and that estradiol increases throughout puberty in girls and boys. This 10-year experience in 800 children shows the range and variability of estradiol by an ultrasensitive bioassay.
评估青春期晚期男孩选择性 mu 阿片受体阻断后黄体生成素和睾酮的瞬时分泌率。
影响因子：
--
作者：
Mauras,N;Rogol,AD;Veldhuis,JD
通讯作者：
Veldhuis,JD
男性雌激素抑制：代谢影响。
DOI：
10.1210/jcem.85.7.6676
发表时间：
2000
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Mauras,N;O'Brien,KO;Klein,KO;Hayes,V
通讯作者：
Hayes,V