Catalytic properties and structural components of lysyl oxidase.
Catalytic properties and structural components of lysyl oxidase.
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赖氨酰氧化酶的催化特性和结构成分。
DOI：
10.1002/9780470514771.ch6
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Csiszar,K
中科院分区：
文献类型：
--
作者：
Kagan,HM;Reddy,VB;Narasimhan,N;Csiszar,K
Key aspects of the biosynthesis and catalytic specificity of lysyl oxidase (LO) have been explored. Oxidation of peptidyl lysine in synthetic oligopeptides is markedly sensitive to the presence of vicinal dicarboxylic ami\no acid residues. Optimal activity is obtained with the ‐Glu‐Lys‐ sequence within a polyglycine 11‐mer, whereas the ‐Lys‐Glu‐ sequence is much less efficiently oxidized. The ‐Asp‐ Glu‐Lys‐ sequence is a very poor substrate, although this sequence is oxidized in type 1 collagen fibrils. These results are considered in the light of a model requiring collagen to be assembled as fibrils prior to oxidation by LO. Anin vitrosystem for the expression of catalytically active LO has been devised. Deletion or inclusion of the cDNA coding for the propeptide region in the expressed construct results in apparently identical, catalytically active enzyme products, indicating the lack of essentiality of this region for active enzyme production. These effects are considered with respect to the conservation of the amino acid sequence of LO produced by different species.
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牛肺和主动脉赖氨酰氧化酶的比较。
影响因子：
2.9
作者：
Cronlund,AL;Kagan,HM
通讯作者：
Kagan,HM
人赖氨酰氧化酶的完整衍生氨基酸序列以及该基因在 5 号染色体上的分配（与鼠 ras 切除基因具有广泛的序列同源性）。
DOI：
--
发表时间：
1992
期刊：
Matrix (Stuttgart, Germany)
影响因子：
--
作者：
Mariani,TJ;Trackman,PC;Kagan,HM;Eddy,RL;Shows,TB;Boyd,CD;Deak,SB
通讯作者：
Deak,SB
DOI：
10.1159/000133500
发表时间：
1993
期刊：
Cytogenetics and cell genetics
影响因子：
--
作者：
Y. S. Chang;D. Svinarich;T. Yang;S. Krawetz
通讯作者：
Y. S. Chang;D. Svinarich;T. Yang;S. Krawetz
鸡主动脉赖氨酰氧化酶的特征和发育表达。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wu,Y;Rich,CB;Lincecum,J;Trackman,PC;Kagan,HM;Foster,JA
通讯作者：
Foster,JA
DOI：
10.1016/s0021-9258(18)82207-4
发表时间：
1993-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
D. Bedell-Hogan;P. Trackman;William AbramsS;Joel RosenbloomS;Herbert Kagang
通讯作者：
D. Bedell-Hogan;P. Trackman;William AbramsS;Joel RosenbloomS;Herbert Kagang