Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome.
Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome.
复制标题
补体激活和皮质类固醇治疗在成人呼吸窘迫综合征的发展中。
作者：
Roland M. H. Schein;Robert Bergman;E. Marcial;Duane R. Schultz;R. C. Duncan;Patricia I. Arnold;Charles L. Sprung
观察了59例感染性休克患者在接受30 mg/kg甲基强的松龙琥珀酸钠、6 mg/kg地塞米松磷酸钠或不使用类固醇之前和之后发生成人呼吸窘迫综合征（ARDS）的情况。C3、C4和因子B的血清水平允许通过补体途径的激活对42名患者进行分类。尽管有一种趋势，即激活旁路途径的严重脓毒性休克患者不会发生ARDS，但补体途径测定不能预测ARDS的发生，类固醇预处理不能影响补体水平或预防ARDS。
Fifty-nine patients in septic shock were observed for the development of the adult respiratory distress syndrome (ARDS) prior to and after receiving either 30 mg/kg methylprednisolone sodium succinate, 6 mg/kg dexamethasone sodium phosphate or no steroid. Serum levels of C3, C4 and Factor B allowed classification of 42 patients by activation of complement pathways. Despite a trend toward patients with severe septic shock who activate the alternative pathway being protected from the development of ARDS, complement pathway determination did not allow prediction of the development of ARDS and steroid pretreatment did not influence complement levels or prevent ARDS.
DOI：
10.1172/jci110548
发表时间：
1982-05
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
G. Till;K. Johnson;R. Kunkel;P. Ward
通讯作者：
G. Till;K. Johnson;R. Kunkel;P. Ward
补体的生物活性产物和败血症综合征患者的急性肺损伤。
DOI：
10.1164/arrd.1984.130.5.791
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Weinberg,PF;Matthay,MA;Webster,RO;Roskos,KV;Goldstein,IM;Murray,JF
通讯作者：
Murray,JF
单次输注酵母聚糖激活血浆对绵羊肺微循环的影响。
DOI：
--
发表时间：
1984
期刊：
The American journal of pathology
影响因子：
--
作者：
Meyrick,BO;Brigham,KL
通讯作者：
Brigham,KL