Construction of 3D Realistic Purkinje System: A Locally Linear Embedding-Based Method

Construction of 3D Realistic Purkinje System: A Locally Linear Embedding-Based Method
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3D 真实浦肯野系统的构建:基于局部线性嵌入的方法

DOI:
10.1142/s0218339010003664
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发表时间:
2010-10
影响因子:
1.6
通讯作者:
Li, Jie
Li, Jie
中科院分区:
生物学4区
文献类型:
--
作者:
Zhang, Henggui;Lu, Weigang;Zuo, Wangmeng;Wang, Kuanquan;Li, Jie

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利用浦肯野系统建立的犬心室几何模型为心室病理生理机制的模拟和分析提供了数据基础。然而,浦肯野系统的几何形状的获取是非常具有挑战性的,传统的构建方法主要是基于使用分形几何建模。在本文中,我们提出了一种新的局部线性嵌入(LLE)为基础的方法来构建犬左心室(LV)的三维解剖浦肯野系统。首先,我们采集了犬心室的二维浦肯野系统数据,并从三维心室中提取了犬左心室的内膜表面。然后,LLE被用来映射的三维几何形状的内表面的二维子空间,和二维浦肯野系统的数据进一步嵌入到这个二维子空间。最后,采用LLE将内表面的3D几何形状和2D浦肯野系统数据映射回3D空间。最后通过实验验证了基于LLE的构造方法的有效性。所提出的方法是很有前途的恢复真实的狗左心室浦肯野系统。
The geometry of canine ventricle with purkinje system provides the data basis for the simulation and analysis of the mechanisms of ventricular pathophysiology. The acquisition of the geometry of the purkinje system, however, is very challenging, and traditional construction approaches are mainly based on modeling using fractal geometry. In this paper, we propose a novel locally linear embedding (LLE)-based method to construct 3D anatomical purkinje system of the canine left ventricle (LV). First, we collect the 2D purkinje system data in a canine ventricle and extract the endocardial surface of the canine left ventricle from 3D canine ventricle. Then, LLE is used to map the 3D geometry of the endocardial surface to a 2D subspace, and the 2D purkinje system data is further embedded into this 2D subspace. Finally, LLE is adopted to map both the 3D geometry of the endocardial surface and the 2D purkinje system data back to the 3D space. An experiment is designed to verify the effectiveness of the LLE-based construction method. The proposed method approaches is promising in restoring realistic purkinje system of the left canine ventricle.
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