Neural correlates of risky decision making in Parkinson's disease patients with impulse control disorders.
Neural correlates of risky decision making in Parkinson's disease patients with impulse control disorders.
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DOI：
10.1007/s00221-022-06423-6
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发表时间：
2022-09
影响因子：
2
通讯作者：
Seidler, Rachael D.
中科院分区：
文献类型：
--
作者：
Ruitenberg, Marit F. L.;Koppelmans, Vincent;Wu, Tina;Averbeck, Bruno B.;Chou, Kelvin L.;Seidler, Rachael D.
一些患有帕金森病（PD）的患者经历冲动控制障碍（ICD），其特征在于对冲动、驱动或关于过度享乐行为的诱惑的自主控制不足。本研究旨在通过解开决策和结局机制中的潜在功能障碍，更好地了解植入ICD的PD患者冲动、冒险决策的神经基础。我们收集了20例植入ICD患者和28例未植入ICD患者的fMRI数据，进行信息收集任务。患者观看从隐藏的骨灰盒中提取的珠子颜色序列，并被指示推断每个骨灰盒中的大多数珠子颜色。对于每一个新的珠子，他们可以选择通过绘制另一个珠子（绘制选择）或进行瓮推理（瓮选择后反馈）来寻找更多的证据。我们通过珠子颜色分裂的概率（80/20 vs. 60/40）和错误推断后的潜在损失（10美元vs. 0美元）来操纵风险。患者还完成了Barratt冲动量表（BIS），以评估冲动。ICD患者在右侧额中回显示出更大的瓮选择特异性激活，与背侧运动前皮质重叠。在所有患者中，较少的抽签选择（即，更多的冲动性）与在各种额叶和顶叶区域、小脑和双侧纹状体的决策和结果处理过程中的更大激活相关。我们的研究结果表明，PD患者的ICD与风险相关信息和结局的神经处理差异相关，涉及奖励和感觉运动多巴胺能通路。
Some patients with Parkinson’s disease (PD) experience impulse control disorders (ICDs), characterized by deficient voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of impulsive, risky decision making in PD patients with ICDs by disentangling potential dysfunctions in decision and outcome mechanisms. We collected fMRI data from 20 patients with ICDs and 28 without ICDs performing an information gathering task. Patients viewed sequences of bead colors drawn from hidden urns and were instructed to infer the majority bead color in each urn. With each new bead, they could choose to either seek more evidence by drawing another bead (draw choice) or make an urn-inference (urn choice followed by feedback). We manipulated risk via the probability of bead color splits (80/20 vs. 60/40) and potential loss following an incorrect inference ($10 vs. $0). Patients also completed the Barratt Impulsiveness Scale (BIS) to assess impulsivity. Patients with ICDs showed greater urn choice-specific activation in the right middle frontal gyrus, overlapping the dorsal premotor cortex. Across all patients, fewer draw choices (i.e., more impulsivity) were associated with greater activation during both decision making and outcome processing in a variety of frontal and parietal areas, cerebellum, and bilateral striatum. Our findings demonstrate that ICDs in PD are associated with differences in neural processing of risk-related information and outcomes, implicating both reward and sensorimotor dopaminergic pathways.
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影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
3.5
作者：
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通讯作者：
Varoquaux G
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影响因子：
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作者：
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通讯作者：
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影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
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影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.