Values encoded in orbitofrontal cortex are causally related to economic choices.
Values encoded in orbitofrontal cortex are causally related to economic choices.
复制标题
在轨道额皮层中编码的值与经济选择有因果关系。
DOI：
10.1038/s41586-020-2880-x
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发表时间：
2020-12
期刊：
影响因子：
64.8
通讯作者：
Padoa-Schioppa C
中科院分区：
文献类型：
--
作者：
Ballesta S;Shi W;Conen KE;Padoa-Schioppa C
在18世纪，丹尼尔·伯努利、亚当·斯密和杰里米·边沁提出，经济选择依赖于主观价值的计算和比较。这一假设继续为现代经济理论和行为经济学研究提供信息，但行为指标最终不足以验证这一假设。与假设一致的是，当代理人做出选择时，眼眶前额叶皮质(OFC)的神经元编码提供和选择的商品的主观价值。编码价值的细胞整合了多个维度，每个细胞组活动的、-、可变性与选择的可变性相关，而种群动态表明决策的形成。然而，目前还不清楚这些神经过程是否与选择有因果关系。更广泛地说，将经济选择与大脑中的价值信号联系起来的证据仍然是相互关联的。我们在这里展示了OFC中的神经元活动是经济选择的因果关系。我们用电刺激在恒河猴(Macaca Mulatta)身上进行了两个实验。低电流刺激增加了个人报价的主观价值，因此可以预见地会出现有偏见的选择。相反，高电流刺激扰乱了主观价值的计算和比较，从而增加了选择的可变性。这些结果表明，OFC编码的主观价值与估值和选择之间存在因果关系。
In the eighteenth century, Daniel Bernoulli, Adam Smith and Jeremy Bentham proposed that economic choices rely on the computation and comparison of subjective values. This hypothesis continues to inform modern economic theory and research in behavioural economics, but behavioural measures are ultimately not sufficient to verify the proposal. Consistent with the hypothesis, when agents make choices, neurons in the orbitofrontal cortex (OFC) encode the subjective value of offered and chosen goods. Value-encoding cells integrate multiple dimensions, , –, variability in the activity of each cell group correlates with variability in choices,and the population dynamics suggests the formation of a decision. However, it is unclear whether these neural processes are causally related to choices. More generally, the evidence linking economic choices to value signals in the brain, –remains correlational. Here we show that neuronal activity in the OFC is causal to economic choices. We conducted two experiments using electrical stimulation in rhesus monkeys (Macaca mulatta). Low-current stimulation increased the subjective value of individual offers and thus predictably biased choices. Conversely, high-current stimulation disrupted both the computation and the comparison of subjective values, and thus increased choice variability. These results demonstrate a causal chain linking subjective values encoded in OFC to valuation and choice.
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影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
额叶中的神经元编码多个决策变量的值。
影响因子：
3.2
作者：
Kennerley SW;Dahmubed AF;Lara AH;Wallis JD
通讯作者：
Wallis JD
影响因子：
16.2
作者：
Padoa-Schioppa C
通讯作者：
Padoa-Schioppa C
影响因子：
9.2
作者：
Ballesta, Sebastien;Padoa-Schioppa, Camillo
通讯作者：
Padoa-Schioppa, Camillo
影响因子：
5.3
作者：
Conen, Katherine E.;Padoa-Schioppa, Camillo
通讯作者：
Padoa-Schioppa, Camillo