Nuclear functions of the HMG proteins.
Nuclear functions of the HMG proteins.
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DOI:
10.1016/j.bbagrm.2009.09.001
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发表时间:
2010-01
期刊:
影响因子:
--
通讯作者:
Reeves R
中科院分区:
文献类型:
--
作者:
Reeves R
Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses on the similarities and differences in the mechanisms by which the different HMG families impact chromatin structure and influence cellular phenotype. The biological implications of having three architectural transcription factor families with complementary, but partially overlapping, nuclear functions are discussed.
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