Nuclear functions of the HMG proteins.

Nuclear functions of the HMG proteins.
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DOI:
10.1016/j.bbagrm.2009.09.001
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发表时间:
2010-01
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
Reeves R
Reeves R
中科院分区:
其他
文献类型:
--
作者:
Reeves R

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尽管哺乳动物 HMG 蛋白的三个家族(HMGA、HMGB 和 HMGN)参与许多相同的核过程,但每个家族在调节染色质结构和调节基因组功能方面发挥着自己独特的作用。本综述重点关注不同 HMG 家族影响染色质结构和细胞表型的机制的异同。讨论了具有互补但部分重叠核功能的三个结构转录因子家族的生物学意义。
Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses on the similarities and differences in the mechanisms by which the different HMG families impact chromatin structure and influence cellular phenotype. The biological implications of having three architectural transcription factor families with complementary, but partially overlapping, nuclear functions are discussed.
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