Age-Related Differences in Mood, Diabetes-Related Distress, and Functional Outcomes in Adults With Type 2 Diabetes Mellitus and Comorbid Obstructive Sleep Apnea and Insomnia.
Age-Related Differences in Mood, Diabetes-Related Distress, and Functional Outcomes in Adults With Type 2 Diabetes Mellitus and Comorbid Obstructive Sleep Apnea and Insomnia.
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DOI：
10.1177/0145721720958396
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Chasens ER
中科院分区：
文献类型：
--
作者：
Jeon B;Sereika SM;Callan JA;Luyster FS;DiNardo MM;Chasens ER
本研究的目的是检查2型糖尿病（T2 DM）合并阻塞性睡眠呼吸暂停（OSA）和失眠的成人患者的情绪、糖尿病相关的痛苦和对睡眠受损敏感的活动的功能结果的年龄相关差异。本研究还评估了年龄、失眠严重程度和OSA严重程度对结果变量的相关性。本研究是对2项随机对照试验的汇总基线数据进行的次要分析，这些试验在有睡眠障碍症状的T2 DM成人患者中进行（N = 145，109名年轻成人，36名老年成人; 46.2%男性; 67.6%白色）。合并OSA和失眠定义为呼吸暂停低通气指数≥ 5起事件/小时和失眠严重程度指数≥ 10。结果变量包括情绪，糖尿病相关的痛苦和功能结果。与年轻人相比，老年人的情绪更好，糖尿病相关的痛苦更低，功能结局更高（所有P <0.05）。胰岛素抵抗严重程度与不良情绪（B = 2.59，P <0.001）和糖尿病相关的痛苦（B = 1.40，P <0.001）以及较低的功能结局（B =-0.22，P <0.001）相关。年龄越大，糖尿病相关的痛苦越少（B =-0.44，P = 0.040）。在患有T2 DM和合并OSA和失眠症的成人患者中，年龄较大是情绪障碍、糖尿病相关痛苦和功能损害的保护性因素。当OSA和失眠并存时，失眠的严重程度与更大的情绪障碍、糖尿病相关的痛苦和功能障碍相关。结果表明，糖尿病护理和教育专家应该评估患者的睡眠障碍。
The purpose of this study was to examine age-related differences in mood, diabetes-related distress, and functional outcomes in activities sensitive to impaired sleep in adults with type 2 diabetes mellitus (T2DM) and comorbid obstructive sleep apnea (OSA) and insomnia. This study also evaluated the associations of age, insomnia severity, and OSA severity on outcome variables. This study was a secondary analysis of pooled baseline data from 2 randomized controlled trials among adults with T2DM with symptoms of sleep disorders (N = 145, 109 younger adults, 36 older adults; 46.2% male; 67.6% White). Comorbid OSA and insomnia was defined as Apnea-hypopnea Index ≥ 5 events per hour and Insomnia Severity Index ≥ 10. Outcome variables included mood, diabetes-related distress, and functional outcomes. Older adults reported better mood, lower diabetes-related distress, and higher functional outcomes relative to younger adults (all Ps < .05). Insomnia severity was associated with worse mood (b = 2.59, P < .001) and diabetes-related distress (b = 1.40, P < .001), and lower functional outcome (b = −0.22, P < .001). Older age was associated with lower diabetes-related distress (b = −0.44, P = .040). Older age was a protective factor of mood disturbance, diabetes-related distress, and functional impairment in adults with T2DM and comorbid OSA and insomnia. Insomnia severity was associated with greater mood disturbance, diabetes-related distress, and functional impairment when OSA and insomnia coexist. The results suggest that diabetes care and education specialists should assess patients for impaired sleep.
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影响因子：
4.7
作者：
Backhaus, J;Junghanns, K;Hohagen, F
通讯作者：
Hohagen, F
影响因子：
4.3
作者：
Berry, Richard B.;Budhiraja, Rohit;Tangredi, Michelle M.
通讯作者：
Tangredi, Michelle M.
影响因子：
5.1
作者：
Azadbakht, Mojtaba;Tanjani, Parisa Taheri;Zanjari, Nasibeh
通讯作者：
Zanjari, Nasibeh
影响因子：
2.5
作者：
Denton, Eve J.;Barnes, Maree;Dabscheck, Eli
通讯作者：
Dabscheck, Eli
DOI：
10.1111/j.1464-5491.2008.02533.x
发表时间：
2008-09
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Fisher L;Skaff MM;Mullan JT;Arean P;Glasgow R;Masharani U
通讯作者：
Masharani U