Longitudinal assessment of sweat-based TNF-alpha in inflammatory bowel disease using a wearable device.
Longitudinal assessment of sweat-based TNF-alpha in inflammatory bowel disease using a wearable device.
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DOI：
10.1038/s41598-024-53522-1
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发表时间：
2024-02-03
影响因子：
4.6
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中科院分区：
文献类型：
--
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可穿戴设备可以无创地监测慢性病患者。汗液是一种易于获取的生物流体，用于连续采样分析物，包括炎症标志物和细胞因子。我们在患有和不患有炎症性肠病（IBD）（胃肠道的一种慢性炎症性疾病）的受试者中评估了汗液传感可穿戴设备。IBD相关住院和C反应蛋白水平高于5 mg/L的参与者佩戴汗液传感可穿戴设备长达5天。通过传感器持续评估汗液中的肿瘤坏死因子-α（TNF-α）水平，并每天评估血液中的水平。第二组无慢性疾病的健康受试者佩戴该设备长达48小时。入组了28例受试者。在16例IBD受试者中，观察到血清和汗液TNF-α水平之间存在中度线性关系（R2 = 0.72）。IBD受试者的平均汗液TNF-α水平为2.11 pg/mL，而12名健康对照者的平均值为0.19 pg/mL（p < 0.0001）。汗液TNF-α测量值可区分活动性IBD受试者与健康受试者，AUC为0.962（95% CI 0.894-1.000）。汗液感测可穿戴设备可以纵向测量IBD的关键的基于汗液的标志物。IBD受试者汗液中的TNF-α水平与血清值相关，表明非侵入性疾病监测的可行性。
Wearable devices can non-invasively monitor patients with chronic diseases. Sweat is an easily accessible biofluid for continuous sampling of analytes, including inflammatory markers and cytokines. We evaluated a sweat sensing wearable device in subjects with and without inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract. Participants with an IBD related hospital admission and a C-reactive protein level above 5 mg/L wore a sweat sensing wearable device for up to 5 days. Tumor necrosis factor-alpha (TNF-α) levels were continually assessed in the sweat via the sensor, and daily in the blood. A second cohort of healthy subjects without chronic diseases wore the device for up to 48 h. Twenty-eight subjects were enrolled. In the 16 subjects with IBD, a moderate linear relationship between serum and sweat TNF-α levels was observed (R2 = 0.72). Subjects with IBD were found to have a mean sweat TNF-α level of 2.11 pg/mL, compared to a mean value of 0.19 pg/mL in 12 healthy controls (p < 0.0001). Sweat TNF-α measurements differentiated subjects with active IBD from healthy subjects with an AUC of 0.962 (95% CI 0.894–1.000). A sweat sensing wearable device can longitudinally measure key sweat-based markers of IBD. TNF-α levels in the sweat of subjects with IBD correlate with serum values, suggesting feasibility in non-invasive disease monitoring.
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