Wearable biosensors for healthcare monitoring.
Wearable biosensors for healthcare monitoring.
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DOI：
10.1038/s41587-019-0045-y
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发表时间：
2019-04
影响因子：
46.9
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Kim J;Campbell AS;de Ávila BE;Wang J
可穿戴生物传感器由于其通过对生物流体（例如汗液、泪液、唾液和间质液（ISF））中的化学标记物的动态非侵入性测量而在一系列医疗保健相关应用中提供连续、实时生理信息的潜力而引起了极大的兴趣。该领域的最新发展集中在电化学和光学生物传感器上，在非侵入性监测新生物标志物方面取得了重大进展，从代谢物到细菌和激素。这些包括多路生物传感方法和微流体采样/传输系统的设计，沿着系统集成和小型化，以及柔性材料，以增强耐磨性和易于操作。现代可穿戴生物传感平台的准确性、有效性和实用性的提高正在增强可靠性和商业影响。即便如此，我们对血液和非侵入性生物流体中分析物浓度之间的相关性的有限理解仍然是一个主要障碍。此外，将需要一组扩展的体上生物亲和性生物测定和额外的传感策略，以扩大可用于监测的生物标志物的范围和类型。为了提高传感器的可靠性，将需要进一步提高生物传感器在不受控条件下的准确性和稳定性，沿着进行可再现的样品运输。总的来说，可穿戴生物传感器被医学和商业界广泛接受将需要通过工程，生物和临床学科之间的多学科合作对其性能进行广泛的大规模人口验证。总的来说，通过可穿戴生物传感技术进行实时身体传感和全面生理信息的通信，为增强个人医疗保健和性能监测提供了重要的前景，并有可能对我们的日常生活产生广泛的影响。
Wearable biosensors are garnering substantial interest due to their potential to provide continuous, real-time physiological information in an array of healthcare-related applications via dynamic non-invasive measurements of chemical markers in biofluids, such as sweat, tears, saliva and interstitial fluid (ISF). Recent developments in this area have focused on electrochemical and optical biosensors, with major advances being made in the non-invasive monitoring of new biomarkers, ranging from metabolites to bacteria and hormones. These include the design of multiplexed biosensing approaches and microfluidic sampling/ transport systems, along with system integration and miniaturization combined with flexible materials for enhanced wearability and ease of operation. The increased accuracy, effectiveness and utility of modern wearable biosensing platforms are enhancing both reliability and commercial impact. Even so, our limited understanding of the correlations between analyte concentrations in the blood and non-invasive biofluids remains a major obstacle. In addition, both an expanded set of on-body bioaffinity bioassays and additional sensing strategies will be required to expand the scope and type of biomarkers accessible to monitoring. Further improvements in biosensor accuracy and stability in uncontrolled conditions, along with reproducible sample transport, will be required for improved sensor reliability. Overall, widespread acceptance of wearable biosensors by the medical and commercial communities will require extensive large population validation of their performance through multidisciplinary collaboration between the engineering, biological and clinical disciplines. Overall, real-time body sensing and communication of comprehensive physiological information via wearable biosensing technologies offer significant promise to enhance personal healthcare and performance monitoring with the potential to have a broad impact on our daily lives.
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DOI：
10.1109/tcsii.2012.2188451
发表时间：
2012-04-01
影响因子：
4.4
作者：
通讯作者：
--
影响因子：
7.4
作者：
Ben-Moshe, Matti;Alexeev, Vladimir L.;Asher, Sanford A.
通讯作者：
Asher, Sanford A.
影响因子：
4.2
作者：
Ballesta Claver, J.;Valencia Miron, M. C.;Capitan-Vallvey, L. F.
通讯作者：
Capitan-Vallvey, L. F.
影响因子：
3
作者：
Bandodkar, Amay J.;Jia, Wenzhao;Wang, Joseph
通讯作者：
Wang, Joseph
DOI：
10.2147/dmso.s32112
发表时间：
2012
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
Abikshyeet P;Ramesh V;Oza N
通讯作者：
Oza N