Association between 5p12 genomic markers and breast cancer susceptibility: evidence from 19 case-control studies.
Association between 5p12 genomic markers and breast cancer susceptibility: evidence from 19 case-control studies.
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DOI：
10.1371/journal.pone.0073611
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Han Y
中科院分区：
文献类型：
--
作者：
Wang X;Zhang L;Chen Z;Ma Y;Zhao Y;Rewuti A;Zhang F;Fu D;Han Y
5 p12基因多态性与乳腺癌（BC）的关联性自首次通过全基因组关联方法发现以来得到了广泛的评价;然而，这些研究产生了相互矛盾的结果。我们试图通过对5 p12上两个广泛研究的多态性（rs 10941679和rs 4415084）进行综合荟萃分析来研究这种不一致性。检索数据库，包括Pubmed、EMBASE、Web of Science、EBSCO和科克伦图书馆数据库，以查找相关研究。比值比（OR）和95%置信区间（CI）用于评估关联强度。应用随机效应模型，解决异质性和发表偏倚。共纳入19篇文章，涉及100，083例病例和163，894例对照。rs 10941679和rs 4415084多态性的每等位基因总体随机效应OR分别为1.09（95%CI：1.06-1.12; P =4.5×10−8）和1.09（95%CI：1.05-1.12; P=4.2×10−7）。 当按种族分层时，在亚洲人和高加索人中发现了显着的结果;而在非洲人/非裔美国人中没有发现显着的关联。使用显性或隐性遗传模型也观察到类似的结果。此外，我们发现rs 4415084和rs 10941679均赋予ER阳性乳腺癌的风险显著高于ER阴性肿瘤。研究结果表明，rs 10941679-G等位基因和rs 4415084-T等位基因可能是乳腺癌发生的危险因素，尤其是在白种人和东亚人中。
The association between polymorphisms on 5p12 and breast cancer (BC) has been widely evaluated since it was first identified through genome-wide association approach; however, the studies have yielded contradictory results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two wildly studied polymorphisms (rs10941679 and rs4415084) on 5p12. Databases including Pubmed, EMBASE, Web of Science, EBSCO, and Cochrane Library databases were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias. A total of 19 articles involving 100,083 cases and 163,894 controls were included. An overall random-effects per-allele OR of 1.09 (95% CI: 1.06–1.12; P = 4.5×10−8) and 1.09 (95% CI: 1.05–1.12; P = 4.2×10−7) was found for the rs10941679 and rs4415084 polymorphism respectively. Significant results were found in Asians and Caucasians when stratified by ethnicity; whereas no significant associations were found among Africans/African-Americans. Similar results were also observed using dominant or recessive genetic models. In addition, we find both rs4415084 and rs10941679 conferred significantly greater risks of ER-positive breast cancer than of ER-negative tumors. Our findings demonstrated that rs10941679-G allele and rs4415084-T allele might be risk-conferring factors for the development of breast cancer, especially in Caucasians and East-Asians.
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DOI：
10.1158/1055-9965.epi-11-0569
发表时间：
2011-10
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Milne RL;Goode EL;García-Closas M;Couch FJ;Severi G;Hein R;Fredericksen Z;Malats N;Zamora MP;Arias Pérez JI;Benítez J;Dörk T;Schürmann P;Karstens JH;Hillemanns P;Cox A;Brock IW;Elliot G;Cross SS;Seal S;Turnbull C;Renwick A;Rahman N;Shen CY;Yu JC;Huang CS;Hou MF;Nordestgaard BG;Bojesen SE;Lanng C;Grenaker Alnæs G;Kristensen V;Børrensen-Dale AL;Hopper JL;Dite GS;Apicella C;Southey MC;Lambrechts D;Yesilyurt BT;Floris G;Leunen K;Sangrajrang S;Gaborieau V;Brennan P;McKay J;Chang-Claude J;Wang-Gohrke S;Radice P;Peterlongo P;Manoukian S;Barile M;Giles GG;Baglietto L;John EM;Miron A;Chanock SJ;Lissowska J;Sherman ME;Figueroa JD;Bogdanova NV;Antonenkova NN;Zalutsky IV;Rogov YI;Fasching PA;Bayer CM;Ekici AB;Beckmann MW;Brenner H;Müller H;Arndt V;Stegmaier C;Andrulis IL;Knight JA;Glendon G;Mulligan AM;Mannermaa A;Kataja V;Kosma VM;Hartikainen JM;Meindl A;Heil J;Bartram CR;Schmutzler RK;Thomas GD;Hoover RN;Fletcher O;Gibson LJ;dos Santos Silva I;Peto J;Nickels S;Flesch-Janys D;Anton-Culver H;Ziogas A;Sawyer E;Tomlinson I;Kerin M;Miller N;Schmidt MK;Broeks A;Van 't Veer LJ;Tollenaar RA;Pharoah PD;Dunning AM;Pooley KA;Marme F;Schneeweiss A;Sohn C;Burwinkel B;Jakubowska A;Lubinski J;Jaworska K;Durda K;Kang D;Yoo KY;Noh DY;Ahn SH;Hunter DJ;Hankinson SE;Kraft P;Lindstrom S;Chen X;Beesley J;Hamann U;Harth V;Justenhoven C;GENICA Network;Winqvist R;Pylkäs K;Jukkola-Vuorinen A;Grip M;Hooning M;Hollestelle A;Oldenburg RA;Tilanus-Linthorst M;Khusnutdinova E;Bermisheva M;Prokofieva D;Farahtdinova A;Olson JE;Wang X;Humphreys MK;Wang Q;Chenevix-Trench G;kConFab Investigators;AOCS Group;Easton DF
通讯作者：
Easton DF
影响因子：
3.8
作者：
Ruiz-Narvaez, Edward A.;Rosenberg, Lynn;Rotimi, Charles N.;Cupples, L. Adrienne;Boggs, Deborah A.;Adeyemo, Adebowale;Cozier, Yvette C.;Adams-Campbell, Lucile L.;Palmer, Julie R.
通讯作者：
Palmer, Julie R.
影响因子：
3.5
作者：
Li, Dawei;Collier, David A.;He, Lin
通讯作者：
He, Lin
影响因子：
3.5
作者：
Koc, EC;Ranasinghe, A;Spremulli, LL
通讯作者：
Spremulli, LL
影响因子：
3.8
作者：
Mcinerney, Niall;Colleran, Gabrielle;Sawyer, Elinor
通讯作者：
Sawyer, Elinor