Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.
Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.
复制标题
DOI：
10.1002/pros.24398
复制
发表时间：
2022-09
期刊：
影响因子：
2.8
通讯作者：
Cohen, Pinchas
中科院分区：
文献类型：
--
作者：
Ramirez-Torres, Adela;Reagan, Allison L.;Howard, Lauren E.;Wiggins, Emily;Vidal, Adriana C.;Wang, Junxiang;Miller, Brendan;Freedland, Stephen J.;Cohen, Pinchas
关键词：
线粒体基因组具有小的开放阅读框架(SORF)，可产生可测量的线粒体衍生多肽(MDP)，包括人素、SHLP2和MOTS-c。以前，在接受前列腺活检的男性中，我们发现在欧洲美国男性(EAM)中，血清SHLP2水平较高与较低的PC风险有关，而在非裔美国男性(AAM)中发现零相关。在这里，在接受前列腺活检的不同患者中，我们通过种族测试了SHLP2、人素和MOTS-c与前列腺癌(PC)风险之间的联系。对198例男性(50/49例EAM/AAM患者和50/49例EAM/AAM对照)的血浆SHLP2、人素和MOTS-c进行了检测。Logistic和多项回归模型检验了每个MDP与PC诊断、低级别(GG1级组)和高级别(GG2-5级)之间的相关性。根据年龄、体重指数、直肠指检和PSA对模型进行了调整。我们测试了MDP和RACE之间的相互作用。在对照组中，人素在种族上相似(P=0.6)，但在AAM组中SHLP2(P=0.007)和MOTS-C(P=0.026)均低于EAM组。在EAM中，较高的MDP值与较低的PC风险相关(均为p-≤0.001)，与aAM中的零相关(所有p-交互作用≤均为0.01)。同样，更高的mdp表达与eAM中低级别和高级别PC的风险降低(均为p≤0.005)与aAM中的空关联相关。在EAM中，较高的MDP水平与较低的PC风险相关，但与AAM无关。一般来说，AAM对照组的MDP水平较低。这些数据支持MDP和PC的线粒体功能障碍，提示AAM的更大功能障碍可能导致过度的PC风险。未来还需要更大规模的研究来证实这些结果。
The mitochondrial genome has small open reading frames (sORF) which produce measurable mitochondrial-derived peptides (MDPs), including humanin, SHLP2, and MOTS-c. Previously, among men undergoing prostate biopsy, we found higher serum SHLP2 was linked with lower PC risk in European American men (EAM), while null associations were found in African American men (AAM). Here, in different patients undergoing prostate biopsy, we tested the link between SHLP2, humanin and MOTS-c and prostate cancer (PC) risk by race. Plasma SHLP2, humanin, and MOTS-c were measured in 198 men (50/49 EAM/AAM cases; 50/49 EAM/AAM controls) undergoing biopsy. Logistic and multinomial regression models tested associations between each MDP and PC diagnosis, low-grade (grade group, GG1) and high-grade (GG2–5). Models were adjusted for age, body mass index, digital rectal examination, and PSA. We tested interactions between MDPs and race. Among controls, humanin was similar by race (p=0.60), but both SHLP2 (p=0.007) and MOTS-c (p=0.026) were lower in AAM controls versus EAM controls. Among EAM, higher MDP values were associated with lower PC risk (all p≤0.001), with null associations in AAM (all p-interactions≤0.01). Similarly, higher MDP expression was associated with decreased risk of low- and high-grade PC in EAM (all p≤0.005) with null associations in AAM. Higher MDP levels were associated with lower PC risk in EAM but not AAM. Generally, AAM controls had lower MDP levels. These data support MDPs and mitochondrial dysfunction in PC, suggesting greater dysfunction in AAM may contribute to excess PC risk. Future larger studies are needed to confirm these results.
登录
查看更多内容
前列腺癌的发病率和生存，按阶段和种族/种族划分 - 美国，2001- 2017年。
DOI：
10.15585/mmwr.mm6941a1
发表时间：
2020-10-16
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Siegel DA;O'Neil ME;Richards TB;Dowling NF;Weir HK
通讯作者：
Weir HK
DOI：
10.1016/j.bbrc.2004.06.133
发表时间：
2004-08-11
影响因子：
3.1
作者：
Xiang, XQ;Saha, AK;Luo, ZJ
通讯作者：
Luo, ZJ
影响因子：
--
作者：
Pandeya, Dipendra Raj;Mittal, Ankush;Bhatta, Bibek
通讯作者：
Bhatta, Bibek
影响因子：
8.2
作者：
Fasulo, Vittorio;Cowan, Janet E.;Carroll, Peter R.
通讯作者：
Carroll, Peter R.
影响因子：
4.8
作者：
Chin, Yung-Ping;Keni, Jyotsna;Cohen, Pinchas
通讯作者：
Cohen, Pinchas