Chronic Inflammation in Obesity and Cancer Cachexia.
Chronic Inflammation in Obesity and Cancer Cachexia.
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DOI：
10.3390/jcm11082191
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发表时间：
2022-04-14
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
长期以来，慢性炎症与肥胖和相关疾病如2型糖尿病和代谢综合征有关。根据目前的研究，患有某些代谢疾病的人患癌症的风险增加可能是由于慢性炎症。脂肪细胞因子是过量分泌的促炎细胞因子，在许多慢性代谢性疾病中升高。细胞因子和炎症介质，不直接连接到DNA，是重要的肿瘤发生。恶病质是一种与疾病相关的代谢综合征，与代谢途径失调有关。肥胖和恶病质具有不同的代谢特征，如胰岛素抵抗、脂解增加、游离脂肪酸（FFA）和神经酰胺水平升高，这些在本节中讨论。本研究项目的目标是建立一个框架，将我们对炎症介导的胰岛素抵抗的知识汇集在一起。
Chronic inflammation has long been linked to obesity and related conditions such as type 2 diabetes and metabolic syndrome. According to current research, the increased risk of cancer in people with certain metabolic diseases may be due to chronic inflammation. Adipocytokines, which are pro-inflammatory cytokines secreted in excess, are elevated in many chronic metabolic diseases. Cytokines and inflammatory mediators, which are not directly linked to DNA, are important in tumorigenesis. Cachexia, a type of metabolic syndrome linked to the disease, is associated with a dysregulation of metabolic pathways. Obesity and cachexia have distinct metabolic characteristics, such as insulin resistance, increased lipolysis, elevated free fatty acids (FFA), and ceramide levels, which are discussed in this section. The goal of this research project is to create a framework for bringing together our knowledge of inflammation-mediated insulin resistance.
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