Development and critical period plasticity of the barrel cortex.
Development and critical period plasticity of the barrel cortex.
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DOI：
10.1111/j.1460-9568.2012.08075.x
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Gaspar P
中科院分区：
文献类型：
--
作者：
Erzurumlu RS;Gaspar P
在哺乳动物的初级感觉新皮质区，感觉受体的分布与地形精度和放大成比例的外周受体密度映射。视觉、躯体感觉和听觉皮层地图是在发育的关键时期建立的。在这段时间里，发育中的皮层地图容易受到感觉器官损伤或感觉剥夺的有害影响。啮齿动物桶皮质提供了一个宝贵的模型系统，调查地形图的形成及其可塑性在发展过程中的机制。鼻端的五排须状毛囊和窦毛阵列由第四层神经模块（“桶”）和初级躯体感觉皮质中的丘脑皮质轴突终末表示。围产期损伤的胡须或感觉神经支配他们不可逆地改变了结构组织的桶。早期的研究强调了感觉周边在决定胡须特定的大脑地图和模式中的作用。分子遗传学的最新进展和对基因改变小鼠的分析使人们对新皮层中神经模式的形成和关键期可塑性的机制有了新的认识。本文就桶状皮层的发育、模式化和关键期可塑性的研究进展作一综述。
In primary sensory neocortical areas of the mammals, the distribution of sensory receptors is mapped with topographic precision and amplification in proportion to the peripheral receptor density. The visual, somatosensory and auditory cortical maps are established during a critical period in development. Throughout this window in time, the developing cortical maps are vulnerable to deleterious effects of sense organ damage or sensory deprivation. The rodent barrel cortex offers an invaluable model system to investigate mechanisms underlying the formation of topographic maps and their plasticity during development. Five rows of mystacial vibrissa (whisker) follicles on the snout and an array of sinus hairs are represented by layer IV neural modules (“barrels”) and thalamocortical axon terminals in the primary somatosensory cortex. Perinatal damage to the whiskers or the sensory nerve innervating them irreversibly alters the structural organization of the barrels. Earlier studies emphasized the role of sensory periphery in dictating whisker-specific brain maps and patterns. Recent advances in molecular genetics and analyses of genetically altered mice allow new insights into neural pattern formation in the neocortex and the mechanisms underlying critical period plasticity. Here we review the development and patterning of the barrel cortex and the critical period plasticity.
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DOI：
10.1073/pnas.92.7.2549
发表时间：
1995-03-28
影响因子：
11.1
作者：
CATALANO, SM;ROBERTSON, RT;KILLACKEY, HP
通讯作者：
KILLACKEY, HP
影响因子：
2.5
作者：
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FOX, K
影响因子：
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Svoboda, Karel
影响因子：
30.8
作者：
Abdel-Majid, RM;Leong, WL;Neumann, PE
通讯作者：
Neumann, PE
影响因子：
3.4
作者：
Baldi, A;Calia, E;Keller, F
通讯作者：
Keller, F