Cognitive deficits of patients with Alzheimer's disease with and without delusions.
Cognitive deficits of patients with Alzheimer's disease with and without delusions.
复制标题
有或没有妄想的阿尔茨海默病患者的认知缺陷。
DOI：
10.1176/ajp.149.2.184
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Thal,LJ
中科院分区：
文献类型：
--
作者：
Jeste,DV;Wragg,RE;Salmon,DP;Harris,MJ;Thal,LJ
本研究的目的是研究阿尔茨海默病妄想的患病率，并比较妄想和非妄想组的神经心理测试battery.MethodThe作者研究了107例阿尔茨海默病患者和51名年龄和教育程度相当的正常人，使用标准化的精神病学访谈和神经心理测试电池。7名阿尔茨海默病患者有妄想症，伴有或不伴有幻觉。妄想症患者在简易精神状态检查、祝福信息-记忆-集中测试、痴呆评定量表，尤其是其概念化和记忆子测试以及语言流畅性测试中的受损程度显著高于无妄想症患者（和正常对照组）。妄想组也往往是有点受损比nondelusional组的修改后的威斯康星州卡片分类测试和相似性子测试的韦氏成人智力量表revised.ConclusionsApproximately三分之一的阿尔茨海默氏病患者的痴呆症发作后的某个时候已经开发出精神病症状。阿尔茨海默病中精神病性症状的存在与更大的认知障碍，特别是额叶/颞叶功能障碍，并可能与更迅速进行性痴呆。
ObjectiveThe goal of this investigation was to study the prevalence of delusions in Alzheimer's disease and to compare the performance of the delusional and nondelusional groups on a neuropsychological test battery.MethodThe authors studied 107 patients with Alzheimer's disease and 51 age-and education-comparable normal subjects using a standardized psychiatric interview and a neuropsychological test battery.ResultsThirty-seven patients with Alzheimer's disease had delusions with or without hallucinations. Patients with delusions were significantly more impaired than those without delusions (and the normal comparison group) on the Mini-Mental State examination; Blessed Information-Memory-Concentration Test; Dementia Rating Scale, especially its conceptualization and memory subtests; and a test of verbal fluency. The delusional group also tended to be somewhat more impaired than the nondelusional group on the modified Wisconsin Card Sorting Test and the similarities subtest of the Wechsler Adult Intelligence Scale-revised.ConclusionsApproximately one-third of patients with Alzheimer's disease had developed psychotic symptoms sometime after the onset of dementia. The presence of psychotic symptoms in Alzheimer's disease was associated with greater cognitive impairment, especially frontal/temporal dysfunction, and possibly with a more rapidly progressive dementia.
登录
查看更多内容
迟发性精神病的临床和诊断特征
DOI：
10.1097/00005053-198508000-00006
发表时间：
1985
期刊：
The Journal of Nervous and Mental Disease
影响因子：
--
作者：
A. Leuchter;J. Spar
通讯作者：
J. Spar
精神分裂症中海马锥体细胞的方向。
影响因子：
--
作者：
Altshuler,LL;Conrad,A;Kovelman,JA;Scheibel,A
通讯作者：
Scheibel,A
影响因子：
--
作者：
L. Robins;J. Helzer;J. Croughan;K. Ratcliff
通讯作者：
L. Robins;J. Helzer;J. Croughan;K. Ratcliff
影响因子：
--
作者：
D. Jeste;J. Lohr
通讯作者：
J. Lohr
DOI：
--
发表时间：
1988
期刊：
The Psychiatric clinics of North America
影响因子：
--
作者：
Pearlson,G;Rabins,P
通讯作者：
Rabins,P