Cardiac Aging: From Basic Research to Therapeutics.

Cardiac Aging: From Basic Research to Therapeutics.
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心脏衰老:从基础研究到治疗

DOI:
10.1155/2021/9570325
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发表时间:
2021
影响因子:
--
通讯作者:
Li J
Li J
中科院分区:
生物学2区
文献类型:
--
作者:
Yan M;Sun S;Xu K;Huang X;Dou L;Pang J;Tang W;Shen T;Li J

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随着长寿研究的进展,我们逐渐认识到心脏衰老会引起心脏结构和功能的改变,包括进行性心肌重塑、左室肥厚、收缩和舒张期功能下降。阐明心脏衰老的调控机制是全世界生物学家和内科医生面临的巨大挑战。在这篇综述中,我们讨论了心脏衰老的几个关键分子机制,以及近年来发展起来的可能的预防和治疗方法。深入了解心脏衰老的过程和机制对于预防与年龄相关的疾病、延长寿命和减轻老年人日益增加的心血管疾病负担是必要的。我们相信,心脏衰老的研究正在进入一个对临床医学和社会福利的进步具有独特意义的新时代。
With research progress on longevity, we have gradually recognized that cardiac aging causes changes in heart structure and function, including progressive myocardial remodeling, left ventricular hypertrophy, and decreases in systolic and diastolic function. Elucidating the regulatory mechanisms of cardiac aging is a great challenge for biologists and physicians worldwide. In this review, we discuss several key molecular mechanisms of cardiac aging and possible prevention and treatment methods developed in recent years. Insights into the process and mechanism of cardiac aging are necessary to protect against age-related diseases, extend lifespan, and reduce the increasing burden of cardiovascular disease in elderly individuals. We believe that research on cardiac aging is entering a new era of unique significance for the progress of clinical medicine and social welfare.
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