Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases.
Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases.
复制标题
DOI：
10.1155/2017/2646904
复制
发表时间：
2017
影响因子：
1.9
通讯作者：
Koizumi N
中科院分区：
文献类型：
--
作者：
Okumura N;Kinoshita S;Koizumi N
ROCK（Rho 激酶）信号传导调节多种基本细胞事件，并参与多种病理状况。因此，它作为对抗各种疾病的潜在治疗靶点引起了研究兴趣。我们发现，抑制 ROCK 可以增强细胞增殖，促进细胞粘附到基质上，并抑制角膜内皮细胞 (CEC) 的凋亡。此外，我们还报道了在动物模型和试点临床研究中，ROCK 抑制剂可以增强角膜内皮的伤口愈合。我们还证明了 ROCK 抑制剂作为组织工程治疗中的辅助药物的有用性，因为它可以增强 CEC 在受体角膜上的植入。 2013年，我们启动了一项临床试验，测试将培养的人类CEC注射到角膜内皮失代偿患者的前房中的有效性。本文回顾了支持 ROCK 抑制剂在临床使用中的效力的累积证据，无论是作为滴眼剂还是作为细胞疗法中的辅助药物，用于治疗角膜内皮失代偿。
ROCK (Rho kinase) signaling regulates a wide spectrum of fundamental cellular events and is involved in a variety of pathological conditions. It has therefore attracted research interest as a potential therapeutic target for combating various diseases. We showed that inhibition of ROCK enhances cell proliferation, promotes cell adhesion onto a substrate, and suppresses apoptosis of corneal endothelial cells (CECs). In addition, we reported that a ROCK inhibitor enhances wound healing in the corneal endothelium in animal models and in pilot clinical research. We also demonstrated the usefulness of a ROCK inhibitor as an adjunct drug in tissue engineering therapy as it enhances the engraftment of CECs onto recipient corneas. In 2013, we initiated a clinical trial to test the effectiveness of injection of cultured human CECs into the anterior chamber of patients with corneal endothelial decompensation. This paper reviews the accumulating evidence supporting the potency of ROCK inhibitors in clinical use, both as eye drops and as adjunct drugs in cell-based therapies, for the treatment of corneal endothelial decompensation.
登录
查看更多内容
角膜水肿在 "角膜切除术 "后消退
影响因子：
2.8
作者：
Braunstein, RE;Airiani, S;Odrich, MG
通讯作者：
Odrich, MG
影响因子：
7.3
作者：
Feng, Yangbo;LoGrasso, Philip V.;Li, Rongshi
通讯作者：
Li, Rongshi
影响因子：
3.9
作者：
Knowles LM;Gurski LA;Maranchie JK;Pilch J
通讯作者：
Pilch J
影响因子：
4.4
作者：
Ishino, Y;Sano, Y;Kinoshita, S
通讯作者：
Kinoshita, S
影响因子：
3.5
作者：
Nakagawa, O;Fujisawa, K;Narumiya, S
通讯作者：
Narumiya, S